人 COPB2 抗体对
01AB03095
Coat protein complex I subunit beta 2 (COPB2) is a cytosolic subunit of the COPI coatomer complex, essential for retrograde vesicular trafficking from the Golgi to the endoplasmic reticulum and intra-Golgi transport. Recruited by ARF GTPases, it recognizes dilysine motifs on cargo proteins to facilitate their retrieval and maintain Golgi structure. COPB2 is also a receptor for activated PKC-epsilon. Pathogenic biallelic variants in COPB2 cause primary autosomal recessive microcephaly 19 (MCPH19) and are associated with developmental delay and osteoporosis, underscoring its critical requirement for neurodevelopment and skeletal homeostasis.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- COPB2
- 蛋白别名
- coat protein complex I subunit beta 2; COPB2
- UniProt
- P35606
- 物种
- Human
产品详情
- 靶点名称
- COPB2
- 蛋白名称
- coat protein complex I subunit beta 2
- 蛋白别名
- Coatomer subunit beta'; Beta'-coat protein; Beta'-COP; p102);COPI coat complex subunit beta 2
- 靶点基因名
- COPB2
- UniProt
- P35606
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Coat protein complex I subunit beta 2 (COPB2) is a cytosolic subunit of the COPI coatomer complex, essential for retrograde vesicular trafficking from the Golgi to the endoplasmic reticulum and intra-Golgi transport. Recruited by ARF GTPases, it recognizes dilysine motifs on cargo proteins to facilitate their retrieval and maintain Golgi structure. COPB2 is also a receptor for activated PKC-epsilon. Pathogenic biallelic variants in COPB2 cause primary autosomal recessive microcephaly 19 (MCPH19) and are associated with developmental delay and osteoporosis, underscoring its critical requirement for neurodevelopment and skeletal homeostasis.