人 COMT 抗体对
01AB03986
Catechol O-methyltransferase (COMT) is an enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, such as dopamine, norepinephrine, and epinephrine, facilitating their degradation. It exists in two isoforms: a soluble form (S-COMT) and a membrane-bound form (MB-COMT), with distinct cellular distributions and functions. COMT plays a critical role in regulating neurotransmitter levels in the brain, particularly in areas like the prefrontal cortex where dopamine signaling is essential for cognitive functions. Dysregulation of COMT has been associated with various psychiatric disorders, including schizophrenia and mood disorders, where genetic polymorphisms, such as the Val158Met variant, can influence enzyme activity and neurotransmitter dynamics.
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技术参数
- 靶点基因名
- COMT
- 蛋白别名
- catechol-O-methyltransferase; COMT
- UniProt
- P21964
- 物种
- Human
产品详情
- 靶点名称
- COMT
- 蛋白名称
- catechol-O-methyltransferase
- 蛋白别名
- Catechol O-methyltransferase
- 靶点基因名
- COMT
- UniProt
- P21964
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Catechol O-methyltransferase (COMT) is an enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, such as dopamine, norepinephrine, and epinephrine, facilitating their degradation. It exists in two isoforms: a soluble form (S-COMT) and a membrane-bound form (MB-COMT), with distinct cellular distributions and functions. COMT plays a critical role in regulating neurotransmitter levels in the brain, particularly in areas like the prefrontal cortex where dopamine signaling is essential for cognitive functions. Dysregulation of COMT has been associated with various psychiatric disorders, including schizophrenia and mood disorders, where genetic polymorphisms, such as the Val158Met variant, can influence enzyme activity and neurotransmitter dynamics.