人 COMMD6 抗体对
01AB03091
COMM domain-containing protein 6 (COMMD6) is a small cytosolic protein defined by a conserved C-terminal COMM domain. It functions within the commander complex to regulate endosomal recycling and protein ubiquitination. COMMD6 acts as a specific repressor of NF-kappaB signaling by binding the RelA subunit, a function dependent on conserved residues within its domain. Through interactions with Cullin-RING E3 ligases, it modulates protein turnover. Dysregulated COMMD6 expression is implicated in cancer biology, influencing tumor progression and immune response modulation via its regulatory effects on inflammatory signaling.
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技术参数
- 靶点基因名
- COMMD6
- 蛋白别名
- COMM domain containing 6; COMMD6
- UniProt
- Q7Z4G1
- 物种
- Human
产品详情
- 靶点名称
- COMMD6
- 蛋白名称
- COMM domain containing 6
- 蛋白别名
- COMM domain-containing protein 6
- 靶点基因名
- COMMD6
- UniProt
- Q7Z4G1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
COMM domain-containing protein 6 (COMMD6) is a small cytosolic protein defined by a conserved C-terminal COMM domain. It functions within the commander complex to regulate endosomal recycling and protein ubiquitination. COMMD6 acts as a specific repressor of NF-kappaB signaling by binding the RelA subunit, a function dependent on conserved residues within its domain. Through interactions with Cullin-RING E3 ligases, it modulates protein turnover. Dysregulated COMMD6 expression is implicated in cancer biology, influencing tumor progression and immune response modulation via its regulatory effects on inflammatory signaling.