人 COLEC12 抗体对
01AB03984
Collectin-12 (COLEC12) is a member of the collectin family of proteins, characterized by its collagen-like structure and carbohydrate recognition domains, which enable it to function as a scavenger receptor in the immune system. COLEC12 plays a crucial role in host defense by binding to carbohydrate antigens on pathogens, facilitating their recognition and clearance. It is involved in the internalization and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells, highlighting its importance in lipid metabolism and inflammation. Dysregulation of COLEC12 has been linked to various diseases, particularly osteosarcoma, where it may influence tumor growth and inflammation through pathways involving Toll-like receptor 4 (TLR4). Increased expression of COLEC12 in cancer-associated stromal cells suggests its potential role in cancer metastasis and immune modulation.
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技术参数
- 靶点基因名
- COLEC12
- 基因别名
- CLP1; NSR2; SCARA4; SRCL
- 蛋白别名
- collectin subfamily member 12; COLEC12
- UniProt
- Q5KU26
- 物种
- Human
产品详情
- 靶点名称
- COLEC12
- 蛋白名称
- collectin subfamily member 12
- 蛋白别名
- Collectin-12; Collectin placenta protein 1; CL-P1; hCL-P1; Nurse cell scavenger receptor 2; Scavenger receptor class A member 4; Scavenger receptor with C-type lectin
- 靶点基因名
- COLEC12
- 基因别名
- CLP1; NSR2; SCARA4; SRCL
- UniProt
- Q5KU26
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Collectin-12 (COLEC12) is a member of the collectin family of proteins, characterized by its collagen-like structure and carbohydrate recognition domains, which enable it to function as a scavenger receptor in the immune system. COLEC12 plays a crucial role in host defense by binding to carbohydrate antigens on pathogens, facilitating their recognition and clearance. It is involved in the internalization and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells, highlighting its importance in lipid metabolism and inflammation. Dysregulation of COLEC12 has been linked to various diseases, particularly osteosarcoma, where it may influence tumor growth and inflammation through pathways involving Toll-like receptor 4 (TLR4). Increased expression of COLEC12 in cancer-associated stromal cells suggests its potential role in cancer metastasis and immune modulation.