抗人 COL23A1 抗体对
01AB02955
Collagen type XXIII alpha 1 chain (COL23A1) is a type II transmembrane non-fibrillar collagen belonging to the transmembrane collagen subfamily. It features a single-pass membrane domain and an extracellular collagenous domain that can be shed as a soluble homotrimer. Expressed in skin and various epithelial tissues, COL23A1 mediates cell-matrix interactions and integrin signaling pathways. While specific Mendelian disorders are not definitively established, altered expression of COL23A1 is observed in certain malignancies, including paraurethral gland cancer, suggesting a role in tumor biology through mechanisms involving cell adhesion and extracellular matrix remodeling.
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技术参数
- 靶点基因名
- COL23A1
- 蛋白别名
- collagen type XXIII alpha 1 chain; COL23A1
- UniProt
- Q86Y22
- 物种
- Human
产品详情
- 靶点名称
- COL23A1
- 蛋白名称
- collagen type XXIII alpha 1 chain
- 蛋白别名
- Collagen alpha-1(XXIII) chain
- 靶点基因名
- COL23A1
- UniProt
- Q86Y22
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Collagen type XXIII alpha 1 chain (COL23A1) is a type II transmembrane non-fibrillar collagen belonging to the transmembrane collagen subfamily. It features a single-pass membrane domain and an extracellular collagenous domain that can be shed as a soluble homotrimer. Expressed in skin and various epithelial tissues, COL23A1 mediates cell-matrix interactions and integrin signaling pathways. While specific Mendelian disorders are not definitively established, altered expression of COL23A1 is observed in certain malignancies, including paraurethral gland cancer, suggesting a role in tumor biology through mechanisms involving cell adhesion and extracellular matrix remodeling.