人 CNTROB 抗体对
01AB01947
Centrobin, centriole duplication and spindle assembly protein (CNTROB) is a centrosomal protein that localizes asymmetrically to the daughter centriole, where it is essential for centriole duplication and elongation. It interacts with tubulin and CPAP to regulate centriole stability and length, ensuring proper spindle assembly and accurate chromosome segregation during mitosis. Furthermore, CNTROB binds to BRCA2, suggesting a functional link between centrosome dynamics and the DNA damage response. Loss of CNTROB leads to significant mitotic defects, including failed centriole duplication and cytokinesis failure, often resulting in the formation of multinucleated cells. Its role in maintaining genomic stability through centrosome integrity makes it a critical factor in cellular homeostasis.
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技术参数
- 靶点基因名
- CNTROB
- 基因别名
- LIP8
- 蛋白别名
- centrobin, centriole duplication and spindle assembly protein; CNTROB
- UniProt
- Q8N137
- 物种
- Human
产品详情
- 靶点名称
- CNTROB
- 蛋白名称
- centrobin, centriole duplication and spindle assembly protein
- 蛋白别名
- Centrobin; Centrosomal BRCA2-interacting protein; LYST-interacting protein 8
- 靶点基因名
- CNTROB
- 基因别名
- LIP8
- UniProt
- Q8N137
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Centrobin, centriole duplication and spindle assembly protein (CNTROB) is a centrosomal protein that localizes asymmetrically to the daughter centriole, where it is essential for centriole duplication and elongation. It interacts with tubulin and CPAP to regulate centriole stability and length, ensuring proper spindle assembly and accurate chromosome segregation during mitosis. Furthermore, CNTROB binds to BRCA2, suggesting a functional link between centrosome dynamics and the DNA damage response. Loss of CNTROB leads to significant mitotic defects, including failed centriole duplication and cytokinesis failure, often resulting in the formation of multinucleated cells. Its role in maintaining genomic stability through centrosome integrity makes it a critical factor in cellular homeostasis.