人 CNPY2 抗体对
01AB03402
Canopy FGF signaling regulator 2 (CNPY2) is a protein localized to the endoplasmic reticulum and plasma membrane that functions as a positive regulator of neurite outgrowth and fibroblast growth factor (FGF) signaling. It contains a saposin B-type domain and acts by stabilizing myosin regulatory light chain, specifically by inhibiting its MIR-mediated ubiquitination and subsequent proteasomal degradation. CNPY2 is expressed across a wide range of human tissues, including the hippocampus, amygdala, and gastrointestinal tract, where it modulates various FGF-dependent pathways, such as those involving FGF21. Clinically, CNPY2 isoform 2 has been identified as a significant prognostic indicator in colorectal cancer, reflecting its role in tumor progression and cellular signaling. Its involvement in stabilizing cytoskeletal components and regulating growth factor pathways highlights its importance in both developmental neurobiology and oncogenic processes.
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技术参数
- 靶点基因名
- CNPY2
- 基因别名
- MSAP; TMEM4; ZSIG9
- 蛋白别名
- canopy FGF signaling regulator 2; CNPY2
- UniProt
- Q9Y2B0
- 物种
- Human
产品详情
- 靶点名称
- CNPY2
- 蛋白名称
- canopy FGF signaling regulator 2
- 蛋白别名
- Protein canopy homolog 2; MIR-interacting saposin-like protein; Putative secreted protein Zsig9; Transmembrane protein 4
- 靶点基因名
- CNPY2
- 基因别名
- MSAP; TMEM4; ZSIG9
- UniProt
- Q9Y2B0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Canopy FGF signaling regulator 2 (CNPY2) is a protein localized to the endoplasmic reticulum and plasma membrane that functions as a positive regulator of neurite outgrowth and fibroblast growth factor (FGF) signaling. It contains a saposin B-type domain and acts by stabilizing myosin regulatory light chain, specifically by inhibiting its MIR-mediated ubiquitination and subsequent proteasomal degradation. CNPY2 is expressed across a wide range of human tissues, including the hippocampus, amygdala, and gastrointestinal tract, where it modulates various FGF-dependent pathways, such as those involving FGF21. Clinically, CNPY2 isoform 2 has been identified as a significant prognostic indicator in colorectal cancer, reflecting its role in tumor progression and cellular signaling. Its involvement in stabilizing cytoskeletal components and regulating growth factor pathways highlights its importance in both developmental neurobiology and oncogenic processes.