人 CNOT1 抗体对
01AB01069
CCR4-NOT transcription complex subunit 1 (CNOT1) is a crucial scaffolding protein within the CCR4-NOT complex, a major cellular mRNA deadenylase responsible for removing poly(A) tails from mRNAs, thereby regulating mRNA stability and degradation. CNOT1 facilitates the assembly and enzymatic activity of the complex by binding other subunits, including enzymatic and non-enzymatic components, and is involved in processes such as negative regulation of intracellular signaling, mRNA processing body (P-body) assembly, and gene expression regulation. Functionally, it contributes to poly(A)-specific ribonuclease activity and interacts with RNA-binding proteins to mediate mRNA decay, miRNA-mediated repression, and translational repression. Structurally, CNOT1 contains armadillo repeat domains enabling molecular adaptor activity and nuclear receptor binding. Deficiency of CNOT1 disrupts CCR4-NOT complex integrity, reduces deadenylase activity, suppresses P-body formation, and induces endoplasmic reticulum stress-mediated apoptosis. Clinically, mutations or dysregulation of CNOT1 are implicated in developmental disorders such as Vissers-Bodmer syndrome and holoprosencephaly 12, and it may contribute to tumorigenesis, including osteosarcoma progression through pathways like Hedgehog signaling.
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技术参数
- 靶点基因名
- CNOT1
- 基因别名
- CDC39; KIAA1007; NOT1
- 蛋白别名
- CCR4-NOT transcription complex subunit 1; CNOT1
- UniProt
- A5YKK6
- 物种
- Human
产品详情
- 靶点名称
- CNOT1
- 蛋白名称
- CCR4-NOT transcription complex subunit 1
- 蛋白别名
- CCR4-NOT transcription complex subunit 1; CCR4-associated factor 1; Negative regulator of transcription subunit 1 homolog; NOT1H; hNOT1
- 靶点基因名
- CNOT1
- 基因别名
- CDC39; KIAA1007; NOT1
- UniProt
- A5YKK6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CCR4-NOT transcription complex subunit 1 (CNOT1) is a crucial scaffolding protein within the CCR4-NOT complex, a major cellular mRNA deadenylase responsible for removing poly(A) tails from mRNAs, thereby regulating mRNA stability and degradation. CNOT1 facilitates the assembly and enzymatic activity of the complex by binding other subunits, including enzymatic and non-enzymatic components, and is involved in processes such as negative regulation of intracellular signaling, mRNA processing body (P-body) assembly, and gene expression regulation. Functionally, it contributes to poly(A)-specific ribonuclease activity and interacts with RNA-binding proteins to mediate mRNA decay, miRNA-mediated repression, and translational repression. Structurally, CNOT1 contains armadillo repeat domains enabling molecular adaptor activity and nuclear receptor binding. Deficiency of CNOT1 disrupts CCR4-NOT complex integrity, reduces deadenylase activity, suppresses P-body formation, and induces endoplasmic reticulum stress-mediated apoptosis. Clinically, mutations or dysregulation of CNOT1 are implicated in developmental disorders such as Vissers-Bodmer syndrome and holoprosencephaly 12, and it may contribute to tumorigenesis, including osteosarcoma progression through pathways like Hedgehog signaling.