人 Clusterin 抗体对
01AB00186
Clusterin (CLU), also known as apolipoprotein J (ApoJ), is a multifunctional glycoprotein involved in various physiological and pathological processes. It is ubiquitously expressed in tissues and bodily fluids, with roles in complement regulation, lipid transport, cell survival, and apoptosis. CLU is traditionally recognized as an extracellular chaperone, but it also has intracellular forms with distinct subcellular localizations, including mitochondrial and nuclear forms. In the context of Alzheimer's disease (AD), CLU has been implicated in the regulation of amyloid beta (Aβ) deposition, aggregation, and clearance, with both pro- and anti-amyloidogenic effects reported. CLU is the third most prominent genetic risk factor for late-onset Alzheimer's disease (LOAD), with several single nucleotide polymorphisms (SNPs) within the CLU locus linked to altered LOAD risk.
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技术参数
- 靶点基因名
- CLU
- 基因别名
- APOJ; CLI; KUB1
- 蛋白别名
- clusterin; Clusterin
- UniProt
- P10909
- 物种
- Human
产品详情
- 靶点名称
- Clusterin
- 蛋白名称
- clusterin
- 蛋白别名
- Clusterin; Aging-associated gene 4 protein; Apolipoprotein J; Apo-J; Complement cytolysis inhibitor; CLI; Complement-associated protein SP-40; 40; Ku70-binding protein 1; NA1/NA2; Sulfated glycoprotein 2; SGP-2; Testosterone-repressed prostate message 2; TRPM-2) [Cleaved into: Clusterin beta chain; ApoJalpha; Complement cytolysis inhibitor a chain; SP-40; 40 beta-chain; Clusterin alpha chain; ApoJbeta; Complement cytolysis inhibitor b chain; SP-40; 40 alpha-chain]
- 靶点基因名
- CLU
- 基因别名
- APOJ; CLI; KUB1
- UniProt
- P10909
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Clusterin (CLU), also known as apolipoprotein J (ApoJ), is a multifunctional glycoprotein involved in various physiological and pathological processes. It is ubiquitously expressed in tissues and bodily fluids, with roles in complement regulation, lipid transport, cell survival, and apoptosis. CLU is traditionally recognized as an extracellular chaperone, but it also has intracellular forms with distinct subcellular localizations, including mitochondrial and nuclear forms. In the context of Alzheimer's disease (AD), CLU has been implicated in the regulation of amyloid beta (Aβ) deposition, aggregation, and clearance, with both pro- and anti-amyloidogenic effects reported. CLU is the third most prominent genetic risk factor for late-onset Alzheimer's disease (LOAD), with several single nucleotide polymorphisms (SNPs) within the CLU locus linked to altered LOAD risk.