人 CLUL1 抗体对
01AB01942
Clusterin like 1 (CLUL1) is a secreted protein that shares structural homology with clusterin (CLU) and is predicted to possess molecular chaperone properties. Unlike the ubiquitously expressed clusterin, CLUL1 exhibits a highly restricted expression pattern, localized primarily to retinal cone photoreceptors. This specificity suggests a specialized role in phototransduction, cone maintenance, and the regulation of extracellular homeostasis within the retina. Functionally, CLUL1 is proposed to participate in protein quality control, ensuring the integrity of the retinal proteome. Although direct biochemical data remain limited, its expression profile indicates it is essential for the specialized physiological requirements of cone cells. By maintaining protein stability and preventing the accumulation of misfolded aggregates, CLUL1 likely supports the long-term viability and function of the photoreceptor layer.
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技术参数
- 靶点基因名
- CLUL1
- 蛋白别名
- clusterin like 1; CLUL1
- UniProt
- Q15846
- 物种
- Human
产品详情
- 靶点名称
- CLUL1
- 蛋白名称
- clusterin like 1
- 蛋白别名
- Clusterin-like protein 1; Retinal-specific clusterin-like protein
- 靶点基因名
- CLUL1
- UniProt
- Q15846
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Clusterin like 1 (CLUL1) is a secreted protein that shares structural homology with clusterin (CLU) and is predicted to possess molecular chaperone properties. Unlike the ubiquitously expressed clusterin, CLUL1 exhibits a highly restricted expression pattern, localized primarily to retinal cone photoreceptors. This specificity suggests a specialized role in phototransduction, cone maintenance, and the regulation of extracellular homeostasis within the retina. Functionally, CLUL1 is proposed to participate in protein quality control, ensuring the integrity of the retinal proteome. Although direct biochemical data remain limited, its expression profile indicates it is essential for the specialized physiological requirements of cone cells. By maintaining protein stability and preventing the accumulation of misfolded aggregates, CLUL1 likely supports the long-term viability and function of the photoreceptor layer.