人 CLSTN3 抗体对
01AB02569
Calsyntenin 3 (CLSTN3) is a type I transmembrane postsynaptic adhesion protein of the cadherin superfamily, primarily enriched in the brain. It localizes to dendrites and the postsynaptic membrane, where it acts as a cell adhesion molecule by binding to presynaptic neurexin-alpha and neurexin-beta. This interaction is essential for organizing both excitatory and inhibitory synapse formation and promoting overall synapse development. CLSTN3 further regulates the excitatory/inhibitory balance, particularly in Purkinje neurons, and participates in ascorbate uptake through its interaction with SLC23A2. Additionally, it forms complexes with amyloid precursor protein (APP) and APBA2, thereby influencing APP processing and contributing to the maintenance of synaptic integrity.
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技术参数
- 靶点基因名
- CLSTN3
- 基因别名
- CS3; KIAA0726
- 蛋白别名
- calsyntenin 3; CLSTN3
- UniProt
- Q9BQT9
- 物种
- Human
产品详情
- 靶点名称
- CLSTN3
- 蛋白名称
- calsyntenin 3
- 蛋白别名
- Calsyntenin-3; Alcadein-beta; Alc-beta
- 靶点基因名
- CLSTN3
- 基因别名
- CS3; KIAA0726
- UniProt
- Q9BQT9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Calsyntenin 3 (CLSTN3) is a type I transmembrane postsynaptic adhesion protein of the cadherin superfamily, primarily enriched in the brain. It localizes to dendrites and the postsynaptic membrane, where it acts as a cell adhesion molecule by binding to presynaptic neurexin-alpha and neurexin-beta. This interaction is essential for organizing both excitatory and inhibitory synapse formation and promoting overall synapse development. CLSTN3 further regulates the excitatory/inhibitory balance, particularly in Purkinje neurons, and participates in ascorbate uptake through its interaction with SLC23A2. Additionally, it forms complexes with amyloid precursor protein (APP) and APBA2, thereby influencing APP processing and contributing to the maintenance of synaptic integrity.