人 CLSTN2 抗体对
01AB03027
Calsyntenin-2 (CLSTN2), also known as alcadein-γ, is a neuronal cell surface protein that plays a critical role in synaptic function and cognitive processes. It is part of the calsyntenin family, which is involved in synapse development and maintenance. CLSTN2 is particularly important for the formation of inhibitory synapses, as its deficiency leads to a reduction in parvalbumin interneurons in the hippocampus and cortex, which are crucial for balanced neural activity. Dysregulation of CLSTN2 has been associated with various neurodevelopmental disorders and cognitive impairments. Studies have shown that mutations or deletions in the CLSTN2 gene can result in deficits in spatial learning and memory, as observed in mouse models. Additionally, genetic variations in CLSTN2 have been linked to human cognitive performance, particularly in episodic memory tasks.
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技术参数
- 靶点基因名
- CLSTN2
- 基因别名
- CS2
- 蛋白别名
- calsyntenin 2; CLSTN2
- UniProt
- Q9H4D0
- 物种
- Human
产品详情
- 靶点名称
- CLSTN2
- 蛋白名称
- calsyntenin 2
- 蛋白别名
- Calsyntenin-2; Alcadein-gamma; Alc-gamma
- 靶点基因名
- CLSTN2
- 基因别名
- CS2
- UniProt
- Q9H4D0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Calsyntenin-2 (CLSTN2), also known as alcadein-γ, is a neuronal cell surface protein that plays a critical role in synaptic function and cognitive processes. It is part of the calsyntenin family, which is involved in synapse development and maintenance. CLSTN2 is particularly important for the formation of inhibitory synapses, as its deficiency leads to a reduction in parvalbumin interneurons in the hippocampus and cortex, which are crucial for balanced neural activity. Dysregulation of CLSTN2 has been associated with various neurodevelopmental disorders and cognitive impairments. Studies have shown that mutations or deletions in the CLSTN2 gene can result in deficits in spatial learning and memory, as observed in mouse models. Additionally, genetic variations in CLSTN2 have been linked to human cognitive performance, particularly in episodic memory tasks.