人 CLSPN 抗体对
01AB03981
Claspin (CLSPN) is a crucial regulatory protein involved in the DNA damage response and replication checkpoint pathways. It functions as a mediator that transmits signals from the ataxia telangiectasia and Rad3-related (ATR) kinase to checkpoint kinase 1 (Chk1), facilitating the activation of the cellular response to replication stress. Claspin is essential for maintaining genomic stability by stabilizing stalled replication forks and ensuring proper DNA repair mechanisms. Dysregulation or mutations in CLSPN have been associated with various diseases, particularly cancer, where its altered expression can lead to increased sensitivity to genotoxic stress and contribute to tumorigenesis. Notably, Claspin has been shown to interact with BRCA1, further linking it to breast cancer susceptibility.
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技术参数
- 靶点基因名
- CLSPN
- 蛋白别名
- claspin; CLSPN
- UniProt
- Q9HAW4
- 物种
- Human
产品详情
- 靶点名称
- CLSPN
- 蛋白名称
- claspin
- 蛋白别名
- Claspin; hClaspin
- 靶点基因名
- CLSPN
- UniProt
- Q9HAW4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Claspin (CLSPN) is a crucial regulatory protein involved in the DNA damage response and replication checkpoint pathways. It functions as a mediator that transmits signals from the ataxia telangiectasia and Rad3-related (ATR) kinase to checkpoint kinase 1 (Chk1), facilitating the activation of the cellular response to replication stress. Claspin is essential for maintaining genomic stability by stabilizing stalled replication forks and ensuring proper DNA repair mechanisms. Dysregulation or mutations in CLSPN have been associated with various diseases, particularly cancer, where its altered expression can lead to increased sensitivity to genotoxic stress and contribute to tumorigenesis. Notably, Claspin has been shown to interact with BRCA1, further linking it to breast cancer susceptibility.