抗人 CLEC4G 抗体对
01AB02999
C-type lectin domain family 4 member G (CLEC4G), also known as LSECtin, is a type II transmembrane protein that belongs to the C-type lectin superfamily. It is primarily expressed on the surface of liver sinusoidal endothelial cells (LSECs) and plays a crucial role in mediating cell-cell interactions and adhesion. CLEC4G contains a carbohydrate recognition domain (CRD) that binds to specific glycans, enabling it to interact with pathogens and facilitate their uptake and clearance by LSECs. Additionally, CLEC4G has been shown to interact with T cells and natural killer cells, suggesting a role in modulating immune responses. Dysregulation of CLEC4G has been linked to various liver diseases, such as viral hepatitis and liver fibrosis, where altered expression or function of the protein may contribute to disease progression.
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技术参数
- 靶点基因名
- CLEC4G
- 蛋白别名
- C-type lectin domain family 4 member G; CLEC4G
- UniProt
- Q6UXB4
- 物种
- Human
产品详情
- 靶点名称
- CLEC4G
- 蛋白名称
- C-type lectin domain family 4 member G
- 蛋白别名
- C-type lectin domain family 4 member G; Liver and lymph node sinusoidal endothelial cell C-type lectin; LSECtin
- 靶点基因名
- CLEC4G
- UniProt
- Q6UXB4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
C-type lectin domain family 4 member G (CLEC4G), also known as LSECtin, is a type II transmembrane protein that belongs to the C-type lectin superfamily. It is primarily expressed on the surface of liver sinusoidal endothelial cells (LSECs) and plays a crucial role in mediating cell-cell interactions and adhesion. CLEC4G contains a carbohydrate recognition domain (CRD) that binds to specific glycans, enabling it to interact with pathogens and facilitate their uptake and clearance by LSECs. Additionally, CLEC4G has been shown to interact with T cells and natural killer cells, suggesting a role in modulating immune responses. Dysregulation of CLEC4G has been linked to various liver diseases, such as viral hepatitis and liver fibrosis, where altered expression or function of the protein may contribute to disease progression.