抗人 CLEC1B 抗体对
01AB00774
C-type lectin domain family 1 member B (CLEC1B), also known as C-type lectin domain family 1 member B, is a type II transmembrane glycoprotein and member of the C-type lectin-like family of receptors. It functions as a pattern recognition receptor, binding to beta-1,3-linked and beta-1,6-linked glucans from fungi and plants. CLEC1B plays a crucial role in platelet activation, tumor cell metastasis, and separation of blood/lymphatic vessels. The protein contains an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. Upon ligand binding, CLEC1B activates signaling pathways involving Syk kinase, leading to platelet activation and inflammatory responses. In terms of disease associations, CLEC1B has been implicated in hepatocellular carcinoma, where its downregulation is associated with tumor vascular invasion and distant metastasis.
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技术参数
- 靶点基因名
- CLEC1B
- 基因别名
- CLEC2
- 蛋白别名
- C-type lectin domain family 1 member B; CLEC1B
- UniProt
- Q9P126
- 物种
- Human
产品详情
- 靶点名称
- CLEC1B
- 蛋白名称
- C-type lectin domain family 1 member B
- 蛋白别名
- C-type lectin domain family 1 member B; C-type lectin-like receptor 2; CLEC-2
- 靶点基因名
- CLEC1B
- 基因别名
- CLEC2
- UniProt
- Q9P126
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
C-type lectin domain family 1 member B (CLEC1B), also known as C-type lectin domain family 1 member B, is a type II transmembrane glycoprotein and member of the C-type lectin-like family of receptors. It functions as a pattern recognition receptor, binding to beta-1,3-linked and beta-1,6-linked glucans from fungi and plants. CLEC1B plays a crucial role in platelet activation, tumor cell metastasis, and separation of blood/lymphatic vessels. The protein contains an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. Upon ligand binding, CLEC1B activates signaling pathways involving Syk kinase, leading to platelet activation and inflammatory responses. In terms of disease associations, CLEC1B has been implicated in hepatocellular carcinoma, where its downregulation is associated with tumor vascular invasion and distant metastasis.