人 CISD1 抗体对
01AB03248
CDGSH iron sulfur domain 1 (CISD1) is a small outer mitochondrial membrane protein that binds a redox-active [2Fe-2S] cluster. It functions as a cluster shuttle protein essential for regulating mitochondrial iron homeostasis, reactive oxygen species balance, and maximal electron transport capacity. By managing the transfer of iron-sulfur clusters, CISD1 supports mitochondrial bioenergetics and protects against oxidative stress. The protein is a key regulator of ferroptosis and is involved in maintaining mitochondrial integrity under metabolic stress. Its activity is critical for cellular redox control, and its dysfunction is associated with impaired ATP production and mitochondrial iron accumulation.
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技术参数
- 靶点基因名
- CISD1
- 基因别名
- C10orf70; ZCD1
- 蛋白别名
- CDGSH iron sulfur domain 1; CISD1
- UniProt
- Q9NZ45
- 物种
- Human
产品详情
- 靶点名称
- CISD1
- 蛋白名称
- CDGSH iron sulfur domain 1
- 蛋白别名
- CDGSH iron-sulfur domain-containing protein 1; Cysteine transaminase CISD1; MitoNEET
- 靶点基因名
- CISD1
- 基因别名
- C10orf70; ZCD1
- UniProt
- Q9NZ45
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CDGSH iron sulfur domain 1 (CISD1) is a small outer mitochondrial membrane protein that binds a redox-active [2Fe-2S] cluster. It functions as a cluster shuttle protein essential for regulating mitochondrial iron homeostasis, reactive oxygen species balance, and maximal electron transport capacity. By managing the transfer of iron-sulfur clusters, CISD1 supports mitochondrial bioenergetics and protects against oxidative stress. The protein is a key regulator of ferroptosis and is involved in maintaining mitochondrial integrity under metabolic stress. Its activity is critical for cellular redox control, and its dysfunction is associated with impaired ATP production and mitochondrial iron accumulation.