人 CIBAR1 抗体对
01AB01941
CBY1 interacting BAR domain containing 1 (CIBAR1) is a membrane-associated protein featuring a BAR domain that binds phospholipids to sense and stabilize membrane curvature. It localizes to ciliary and flagellar structures, where it cooperates with the basal-body protein CBY1 and related Cby proteins to regulate ciliogenesis and inner mitochondrial membrane organization. CIBAR1 is essential for the proper positioning of the annulus, a septin-based ring that separates the sperm midpiece from the principal piece, thereby maintaining the membrane diffusion barrier. Loss of CIBAR1 function leads to structural defects in sperm flagella, resulting in impaired motility and male subfertility or infertility. Beyond its role in spermatogenesis, CIBAR1 is involved in limb morphogenesis and other developmental processes, suggesting that its perturbation may contribute to ciliopathy-like phenotypes.
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技术参数
- 靶点基因名
- CIBAR1
- 基因别名
- FAM92A; FAM92A1
- 蛋白别名
- CBY1 interacting BAR domain containing 1; CIBAR1
- UniProt
- A1XBS5
- 物种
- Human
产品详情
- 靶点名称
- CIBAR1
- 蛋白名称
- CBY1 interacting BAR domain containing 1
- 蛋白别名
- CBY1-interacting BAR domain-containing protein 1
- 靶点基因名
- CIBAR1
- 基因别名
- FAM92A; FAM92A1
- UniProt
- A1XBS5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CBY1 interacting BAR domain containing 1 (CIBAR1) is a membrane-associated protein featuring a BAR domain that binds phospholipids to sense and stabilize membrane curvature. It localizes to ciliary and flagellar structures, where it cooperates with the basal-body protein CBY1 and related Cby proteins to regulate ciliogenesis and inner mitochondrial membrane organization. CIBAR1 is essential for the proper positioning of the annulus, a septin-based ring that separates the sperm midpiece from the principal piece, thereby maintaining the membrane diffusion barrier. Loss of CIBAR1 function leads to structural defects in sperm flagella, resulting in impaired motility and male subfertility or infertility. Beyond its role in spermatogenesis, CIBAR1 is involved in limb morphogenesis and other developmental processes, suggesting that its perturbation may contribute to ciliopathy-like phenotypes.