抗人 cIAP2 抗体对
01AB01032
Baculoviral IAP repeat containing 3 (BIRC3), also known as cIAP2, is a multifunctional protein that belongs to the inhibitor of apoptosis (IAP) family and plays a crucial role in regulating apoptosis, inflammation, and immune signaling. Structurally, BIRC3 contains three baculoviral IAP repeat (BIR) domains, a ubiquitin-associated (UBA) domain, a caspase recruitment domain (CARD), and a RING finger domain, which collectively enable it to inhibit caspases and modulate various signaling pathways, including those involved in mitogenic kinase activity and inflammatory responses. BIRC3 interacts with tumor necrosis factor receptor-associated factors (TRAF1 and TRAF2), thereby inhibiting apoptosis and influencing cell survival, particularly under conditions such as serum deprivation. The protein is widely expressed across tissues, including immune and endocrine organs, and its function can be further diversified by alternative 3' untranslated regions (3' UTRs) that facilitate the assembly of specific protein complexes, impacting processes like B cell migration. Dysregulation or mutation of BIRC3 has been implicated in various diseases, notably certain leukemias and lymphomas, where altered BIRC3 function can contribute to abnormal cell survival and resistance to apoptosis.
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技术参数
- 靶点基因名
- BIRC3
- 基因别名
- API2; MIHC; RNF49
- 蛋白别名
- baculoviral IAP repeat containing 3; cIAP2
- UniProt
- Q13489
- 物种
- Human
产品详情
- 靶点名称
- cIAP2
- 蛋白名称
- baculoviral IAP repeat containing 3
- 蛋白别名
- Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2; Cellular inhibitor of apoptosis 2; C-IAP2; IAP homolog C; Inhibitor of apoptosis protein 1; hIAP-1; hIAP1; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF-signaling complex protein 1
- 靶点基因名
- BIRC3
- 基因别名
- API2; MIHC; RNF49
- UniProt
- Q13489
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Baculoviral IAP repeat containing 3 (BIRC3), also known as cIAP2, is a multifunctional protein that belongs to the inhibitor of apoptosis (IAP) family and plays a crucial role in regulating apoptosis, inflammation, and immune signaling. Structurally, BIRC3 contains three baculoviral IAP repeat (BIR) domains, a ubiquitin-associated (UBA) domain, a caspase recruitment domain (CARD), and a RING finger domain, which collectively enable it to inhibit caspases and modulate various signaling pathways, including those involved in mitogenic kinase activity and inflammatory responses. BIRC3 interacts with tumor necrosis factor receptor-associated factors (TRAF1 and TRAF2), thereby inhibiting apoptosis and influencing cell survival, particularly under conditions such as serum deprivation. The protein is widely expressed across tissues, including immune and endocrine organs, and its function can be further diversified by alternative 3' untranslated regions (3' UTRs) that facilitate the assembly of specific protein complexes, impacting processes like B cell migration. Dysregulation or mutation of BIRC3 has been implicated in various diseases, notably certain leukemias and lymphomas, where altered BIRC3 function can contribute to abnormal cell survival and resistance to apoptosis.