抗人 CHST4 抗体对
01AB00771
Carbohydrate sulfotransferase 4 (CHST4) is a Golgi-localized enzyme that belongs to the GlcNAc6ST family and catalyzes the transfer of sulfate to the 6-hydroxyl position of N-acetylglucosamine residues on glycan structures, particularly on ligands of the lymphocyte homing receptor L-selectin. This sulfation is crucial for the proper modification of mucin-type O-glycans, especially core 2-branched structures, and plays a significant role in modulating lymphocyte rolling velocity and the selective recruitment of T and B lymphocytes into peripheral lymph nodes, with a major function in B cell homing. Functionally, CHST4 influences immune cell trafficking and is implicated in immune surveillance. In disease contexts, elevated CHST4 expression has been associated with a favorable prognosis in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC), likely due to its role in recruiting immune cells with tumor-killing activity into the tumor microenvironment, thereby inhibiting tumor progression.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- CHST4
- 蛋白别名
- carbohydrate sulfotransferase 4; CHST4
- UniProt
- Q8NCG5
- 物种
- Human
产品详情
- 靶点名称
- CHST4
- 蛋白名称
- carbohydrate sulfotransferase 4
- 蛋白别名
- Carbohydrate sulfotransferase 4; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3; GST-3; High endothelial cells N-acetylglucosamine 6-O-sulfotransferase; HEC-GlcNAc6ST; L-selectin ligand sulfotransferase; LSST; N-acetylglucosamine 6-O-sulfotransferase 2; GlcNAc6ST-2; Gn6st-2
- 靶点基因名
- CHST4
- UniProt
- Q8NCG5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Carbohydrate sulfotransferase 4 (CHST4) is a Golgi-localized enzyme that belongs to the GlcNAc6ST family and catalyzes the transfer of sulfate to the 6-hydroxyl position of N-acetylglucosamine residues on glycan structures, particularly on ligands of the lymphocyte homing receptor L-selectin. This sulfation is crucial for the proper modification of mucin-type O-glycans, especially core 2-branched structures, and plays a significant role in modulating lymphocyte rolling velocity and the selective recruitment of T and B lymphocytes into peripheral lymph nodes, with a major function in B cell homing. Functionally, CHST4 influences immune cell trafficking and is implicated in immune surveillance. In disease contexts, elevated CHST4 expression has been associated with a favorable prognosis in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC), likely due to its role in recruiting immune cells with tumor-killing activity into the tumor microenvironment, thereby inhibiting tumor progression.