人 CHRDL2 抗体对
01AB03974
Chordin-like 2 (CHRDL2) is a protein encoded by the CHRDL2 gene located on chromosome 11 in humans. This protein plays a crucial role in various biological processes, particularly in cell proliferation and tumorigenesis. It has been implicated in promoting the proliferation of gastric cancer cells by activating the YAP/TAZ signaling pathway, which is essential for cellular growth and survival. Additionally, CHRDL2 acts as an inhibitor of bone morphogenetic proteins (BMPs), potentially affecting their interaction with receptors and thereby influencing developmental processes and disease mechanisms. Dysregulation of CHRDL2 has been associated with several cancers, including osteosarcoma, where it promotes not only cell proliferation but also metastasis. Overall, CHRDL2 is emerging as a significant player in cancer biology, highlighting its potential as a therapeutic target.
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技术参数
- 靶点基因名
- CHRDL2
- 基因别名
- BNF1; CHL2
- 蛋白别名
- chordin like 2; CHRDL2
- UniProt
- Q6WN34
- 物种
- Human
产品详情
- 靶点名称
- CHRDL2
- 蛋白名称
- chordin like 2
- 蛋白别名
- Chordin-like protein 2; Breast tumor novel factor 1; BNF-1; Chordin-related protein 2
- 靶点基因名
- CHRDL2
- 基因别名
- BNF1; CHL2
- UniProt
- Q6WN34
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Chordin-like 2 (CHRDL2) is a protein encoded by the CHRDL2 gene located on chromosome 11 in humans. This protein plays a crucial role in various biological processes, particularly in cell proliferation and tumorigenesis. It has been implicated in promoting the proliferation of gastric cancer cells by activating the YAP/TAZ signaling pathway, which is essential for cellular growth and survival. Additionally, CHRDL2 acts as an inhibitor of bone morphogenetic proteins (BMPs), potentially affecting their interaction with receptors and thereby influencing developmental processes and disease mechanisms. Dysregulation of CHRDL2 has been associated with several cancers, including osteosarcoma, where it promotes not only cell proliferation but also metastasis. Overall, CHRDL2 is emerging as a significant player in cancer biology, highlighting its potential as a therapeutic target.