人 CHRDL1 抗体对
01AB03971
Chordin-like 1 (CHRDL1) is a secreted glycoprotein that functions primarily as an antagonist of bone morphogenetic proteins (BMPs), particularly BMP-4. It plays crucial roles in various biological processes, including osteogenesis, neurogenesis, and tumor suppression. CHRDL1 is involved in the differentiation of osteoblasts and adipocytes, with studies indicating that it promotes adipogenesis while suppressing osteogenic differentiation through modulation of signaling pathways, including AKT/mTORC1 and interactions with insulin-like growth factor binding protein 3 (IGFBP3). Dysregulation of CHRDL1 has been linked to several diseases, notably non-syndromic X-linked megalocornea due to mutations affecting its function, and various cancers where it may act as a tumor suppressor or promoter depending on the context.
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技术参数
- 靶点基因名
- CHRDL1
- 基因别名
- NRLN1
- 蛋白别名
- chordin like 1; CHRDL1
- UniProt
- Q9BU40
- 物种
- Human
产品详情
- 靶点名称
- CHRDL1
- 蛋白名称
- chordin like 1
- 蛋白别名
- Chordin-like protein 1; Neuralin-1; Neurogenesin-1; Ventroptin
- 靶点基因名
- CHRDL1
- 基因别名
- NRLN1
- UniProt
- Q9BU40
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Chordin-like 1 (CHRDL1) is a secreted glycoprotein that functions primarily as an antagonist of bone morphogenetic proteins (BMPs), particularly BMP-4. It plays crucial roles in various biological processes, including osteogenesis, neurogenesis, and tumor suppression. CHRDL1 is involved in the differentiation of osteoblasts and adipocytes, with studies indicating that it promotes adipogenesis while suppressing osteogenic differentiation through modulation of signaling pathways, including AKT/mTORC1 and interactions with insulin-like growth factor binding protein 3 (IGFBP3). Dysregulation of CHRDL1 has been linked to several diseases, notably non-syndromic X-linked megalocornea due to mutations affecting its function, and various cancers where it may act as a tumor suppressor or promoter depending on the context.