抗人 CHML 抗体对
01AB00768
CHM like Rab escort protein (CHML) is a substrate-binding subunit of the Rab geranylgeranyltransferase complex that binds unprenylated Rab proteins and presents them to the catalytic subunit for geranylgeranyl transfer. This process is essential for proper Rab protein localization to intracellular membranes. CHML is structurally related to GDI and plays a crucial role in loading prenylated RabGTPases onto target membranes. The protein may substitute for REP-1 (encoded by the CHM gene) in tissues other than retina, supporting geranylgeranylation of most Rab proteins. Recent research indicates that CHML promotes migration, invasion, and metastasis of hepatocellular carcinoma cells in a Rab14-dependent manner, suggesting its potential role in cancer progression.
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技术参数
- 靶点基因名
- CHML
- 基因别名
- REP2
- 蛋白别名
- CHM like Rab escort protein; CHML
- UniProt
- P26374
- 物种
- Human
产品详情
- 靶点名称
- CHML
- 蛋白名称
- CHM like Rab escort protein
- 蛋白别名
- Rab proteins geranylgeranyltransferase component A 2; Choroideremia-like protein; Rab escort protein 2; REP-2
- 靶点基因名
- CHML
- 基因别名
- REP2
- UniProt
- P26374
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CHM like Rab escort protein (CHML) is a substrate-binding subunit of the Rab geranylgeranyltransferase complex that binds unprenylated Rab proteins and presents them to the catalytic subunit for geranylgeranyl transfer. This process is essential for proper Rab protein localization to intracellular membranes. CHML is structurally related to GDI and plays a crucial role in loading prenylated RabGTPases onto target membranes. The protein may substitute for REP-1 (encoded by the CHM gene) in tissues other than retina, supporting geranylgeranylation of most Rab proteins. Recent research indicates that CHML promotes migration, invasion, and metastasis of hepatocellular carcinoma cells in a Rab14-dependent manner, suggesting its potential role in cancer progression.