人 CHAD 抗体对
01AB01937
Chondroadherin (CHAD) is a small leucine-rich repeat proteoglycan located in the extracellular matrix, primarily enriched in cartilage and bone. It mediates the attachment of chondrocytes, osteoblasts, and fibroblasts by binding to integrin α2β1 and syndecans, thereby linking the extracellular environment to intracellular signaling pathways such as PI3K-Akt. CHAD interacts with various collagens to facilitate early matrix assembly and maintain the mechanical integrity of skeletal tissues. Its expression throughout different developmental stages suggests a continuous role in regulating chondrocyte proliferation and matrix homeostasis. Clinically, CHAD is associated with musculoskeletal disorders, including calcific tendinitis and osteochondrodysplasia, and its deficiency is known to result in altered bone density and mechanical properties.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- CHAD
- 基因别名
- SLRR4A
- 蛋白别名
- chondroadherin; CHAD
- UniProt
- O15335
- 物种
- Human
产品详情
- 靶点名称
- CHAD
- 蛋白名称
- chondroadherin
- 蛋白别名
- Chondroadherin; Cartilage leucine-rich protein
- 靶点基因名
- CHAD
- 基因别名
- SLRR4A
- UniProt
- O15335
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Chondroadherin (CHAD) is a small leucine-rich repeat proteoglycan located in the extracellular matrix, primarily enriched in cartilage and bone. It mediates the attachment of chondrocytes, osteoblasts, and fibroblasts by binding to integrin α2β1 and syndecans, thereby linking the extracellular environment to intracellular signaling pathways such as PI3K-Akt. CHAD interacts with various collagens to facilitate early matrix assembly and maintain the mechanical integrity of skeletal tissues. Its expression throughout different developmental stages suggests a continuous role in regulating chondrocyte proliferation and matrix homeostasis. Clinically, CHAD is associated with musculoskeletal disorders, including calcific tendinitis and osteochondrodysplasia, and its deficiency is known to result in altered bone density and mechanical properties.