人 CFC1 抗体对
01AB01454
Cryptic, EGF-CFC family member 1 (CFC1) is a protein encoded by the CFC1 gene located on chromosome 2 and is a member of the EGF-CFC family, which includes structurally related proteins characterized by a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. These proteins act as competence factors during early embryogenesis, playing essential roles in mesoderm and endoderm formation, anterior/posterior axis establishment, and particularly in left-right (L/R) axis patterning. CFC1 is necessary for proper signaling of the TGFβ-related gene nodal during gastrulation and L/R asymmetry development, and its expression is critical in early heart development. Mutations in CFC1 are associated with developmental defects such as autosomal visceral heterotaxy and congenital heart disease.
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技术参数
- 靶点基因名
- CFC1
- 蛋白别名
- cryptic, EGF-CFC family member 1; CFC1
- UniProt
- P0CG37
- 物种
- Human
产品详情
- 靶点名称
- CFC1
- 蛋白名称
- cryptic, EGF-CFC family member 1
- 蛋白别名
- Cryptic protein; Cryptic family protein 1
- 靶点基因名
- CFC1
- UniProt
- P0CG37
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cryptic, EGF-CFC family member 1 (CFC1) is a protein encoded by the CFC1 gene located on chromosome 2 and is a member of the EGF-CFC family, which includes structurally related proteins characterized by a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. These proteins act as competence factors during early embryogenesis, playing essential roles in mesoderm and endoderm formation, anterior/posterior axis establishment, and particularly in left-right (L/R) axis patterning. CFC1 is necessary for proper signaling of the TGFβ-related gene nodal during gastrulation and L/R asymmetry development, and its expression is critical in early heart development. Mutations in CFC1 are associated with developmental defects such as autosomal visceral heterotaxy and congenital heart disease.