人 CEP57L1 抗体对
01AB01655
Centrosomal protein 57 like 1 (CEP57L1) is a centrosomal scaffold protein that localizes to the microtubule-organizing center and is essential for maintaining centrosomal architecture. Together with its paralog CEP57, it redundantly regulates centriole engagement during interphase, preventing precocious disengagement and abnormal centriole reduplication. CEP57L1 also plays a role in mitotic spindle organization by tethering the minus ends of spindle microtubules and facilitating their attachment to kinetochores. Clinically, reduced expression of CEP57L1 has been specifically associated with the congenital absence of the anterior and posterior cruciate ligaments in the knee, indicating a specialized role in musculoskeletal development.
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技术参数
- 靶点基因名
- CEP57L1
- 基因别名
- C6orf182; CEP57R
- 蛋白别名
- centrosomal protein 57 like 1; CEP57L1
- UniProt
- Q8IYX8
- 物种
- Human
产品详情
- 靶点名称
- CEP57L1
- 蛋白名称
- centrosomal protein 57 like 1
- 蛋白别名
- Centrosomal protein CEP57L1; Centrosomal protein 57kDa-like protein 1; Centrosomal protein of 57 kDa-related protein; Cep57R; Cep57-related protein
- 靶点基因名
- CEP57L1
- 基因别名
- C6orf182; CEP57R
- UniProt
- Q8IYX8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Centrosomal protein 57 like 1 (CEP57L1) is a centrosomal scaffold protein that localizes to the microtubule-organizing center and is essential for maintaining centrosomal architecture. Together with its paralog CEP57, it redundantly regulates centriole engagement during interphase, preventing precocious disengagement and abnormal centriole reduplication. CEP57L1 also plays a role in mitotic spindle organization by tethering the minus ends of spindle microtubules and facilitating their attachment to kinetochores. Clinically, reduced expression of CEP57L1 has been specifically associated with the congenital absence of the anterior and posterior cruciate ligaments in the knee, indicating a specialized role in musculoskeletal development.