抗人 CEP170B 抗体对
01AB03367
Centrosomal protein 170B (CEP170B) is a 170 kDa microtubule-associated protein that plays a vital role in microtubule organization during mitosis and ciliogenesis. It binds microtubules with high affinity, facilitating their bundling during interphase and serving as a scaffold for spindle-associated proteins. Specifically, CEP170B interacts with kinesin-13 family members, such as KIF2B, to target them to the mitotic spindle, where they promote the microtubule depolymerization necessary for accurate chromosome segregation. Additionally, the protein is essential for cilia homeostasis; it interacts with dynein-2 to promote holoenzyme assembly and intraflagellar transport (IFT). Loss of CEP170B leads to significant IFT defects, delayed cilia disassembly, and perturbed Hedgehog signaling. Through these mechanisms, CEP170B acts as a central hub for coordinating the microtubule dynamics required for both cellular division and specialized sensory organelle function.
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技术参数
- 靶点基因名
- CEP170B
- 基因别名
- FAM68C; KIAA0284
- 蛋白别名
- centrosomal protein 170B; CEP170B
- UniProt
- Q9Y4F5
- 物种
- Human
产品详情
- 靶点名称
- CEP170B
- 蛋白名称
- centrosomal protein 170B
- 蛋白别名
- Centrosomal protein of 170 kDa protein B; Centrosomal protein 170B; Cep170B
- 靶点基因名
- CEP170B
- 基因别名
- FAM68C; KIAA0284
- UniProt
- Q9Y4F5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Centrosomal protein 170B (CEP170B) is a 170 kDa microtubule-associated protein that plays a vital role in microtubule organization during mitosis and ciliogenesis. It binds microtubules with high affinity, facilitating their bundling during interphase and serving as a scaffold for spindle-associated proteins. Specifically, CEP170B interacts with kinesin-13 family members, such as KIF2B, to target them to the mitotic spindle, where they promote the microtubule depolymerization necessary for accurate chromosome segregation. Additionally, the protein is essential for cilia homeostasis; it interacts with dynein-2 to promote holoenzyme assembly and intraflagellar transport (IFT). Loss of CEP170B leads to significant IFT defects, delayed cilia disassembly, and perturbed Hedgehog signaling. Through these mechanisms, CEP170B acts as a central hub for coordinating the microtubule dynamics required for both cellular division and specialized sensory organelle function.