人 CDSN 抗体对
01AB02054
Corneodesmosin (CDSN) is a secreted glycoprotein highly enriched in serine and glycine, predominantly localized in corneodesmosomes of the human epidermis and other cornified squamous epithelia, where it plays a crucial role in cell-cell adhesion and the maintenance of skin barrier integrity. The protein is covalently linked to the cornified envelope of corneocytes and is sequentially proteolyzed as corneocytes migrate toward the skin surface, a process essential for proper desquamation and epidermal differentiation. Its N-terminal glycine-rich domain is particularly important for adhesive properties, mediating homophilic interactions that contribute to corneocyte cohesion. Mutations in CDSN, especially nonsense mutations leading to truncated proteins, are associated with rare autosomal dominant hypotrichosis simplex of the scalp, characterized by progressive hair loss, and have been implicated in skin barrier defects and susceptibility to psoriasis.
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技术参数
- 靶点基因名
- CDSN
- 蛋白别名
- corneodesmosin; CDSN
- UniProt
- Q15517
- 物种
- Human
产品详情
- 靶点名称
- CDSN
- 蛋白名称
- corneodesmosin
- 蛋白别名
- Corneodesmosin; S protein
- 靶点基因名
- CDSN
- UniProt
- Q15517
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Corneodesmosin (CDSN) is a secreted glycoprotein highly enriched in serine and glycine, predominantly localized in corneodesmosomes of the human epidermis and other cornified squamous epithelia, where it plays a crucial role in cell-cell adhesion and the maintenance of skin barrier integrity. The protein is covalently linked to the cornified envelope of corneocytes and is sequentially proteolyzed as corneocytes migrate toward the skin surface, a process essential for proper desquamation and epidermal differentiation. Its N-terminal glycine-rich domain is particularly important for adhesive properties, mediating homophilic interactions that contribute to corneocyte cohesion. Mutations in CDSN, especially nonsense mutations leading to truncated proteins, are associated with rare autosomal dominant hypotrichosis simplex of the scalp, characterized by progressive hair loss, and have been implicated in skin barrier defects and susceptibility to psoriasis.