人 CDON 抗体对
01AB03853
Cell adhesion molecule-related/down-regulated by oncogenes (CDON) is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in cell signaling and development. CDON is involved in myogenic differentiation and is crucial for the regulation of neural crest cell migration by interacting with N-cadherin. It acts as a receptor for hedgehog (Hh) proteins, including Sonic Hh, Indian Hh, and Desert Hh, thereby modulating Hh signaling pathways critical for cell proliferation and differentiation during embryonic development. Dysregulation of CDON has been associated with several developmental disorders, particularly holoprosencephaly, a condition characterized by the failure of the forebrain to separate properly into hemispheres. Additionally, CDON has been implicated in other conditions, such as optic nerve hypoplasia and cardiac dysfunction, particularly when combined with environmental factors like prenatal alcohol exposure.
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技术参数
- 靶点基因名
- CDON
- 基因别名
- CDO
- 蛋白别名
- cell adhesion associated, oncogene regulated; CDON
- UniProt
- Q4KMG0
- 物种
- Human
产品详情
- 靶点名称
- CDON
- 蛋白名称
- cell adhesion associated, oncogene regulated
- 蛋白别名
- Cell adhesion molecule-related/down-regulated by oncogenes
- 靶点基因名
- CDON
- 基因别名
- CDO
- UniProt
- Q4KMG0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cell adhesion molecule-related/down-regulated by oncogenes (CDON) is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in cell signaling and development. CDON is involved in myogenic differentiation and is crucial for the regulation of neural crest cell migration by interacting with N-cadherin. It acts as a receptor for hedgehog (Hh) proteins, including Sonic Hh, Indian Hh, and Desert Hh, thereby modulating Hh signaling pathways critical for cell proliferation and differentiation during embryonic development. Dysregulation of CDON has been associated with several developmental disorders, particularly holoprosencephaly, a condition characterized by the failure of the forebrain to separate properly into hemispheres. Additionally, CDON has been implicated in other conditions, such as optic nerve hypoplasia and cardiac dysfunction, particularly when combined with environmental factors like prenatal alcohol exposure.