人 CDKL2 抗体对
01AB01056
Cyclin dependent kinase like 2 (CDKL2) is a serine/threonine protein kinase encoded by the CDKL2 gene in humans. It is a member of the CDC2-related protein kinase family and accumulates primarily in the cytoplasm, with lower levels in the nucleus. CDKL2 exhibits ATP binding and protein serine/threonine kinase activity, playing a role in cell cycle regulation and cognitive functions. The protein is highly expressed in regions associated with cognition and emotion, such as the hippocampal formation and amygdala. CDKL2 is involved in the regulation of epithelial-mesenchymal transition (EMT) and has been implicated in tumor progression. Decreased CDKL2 expression correlates with poor prognosis in glioma. Additionally, CDKL2 has been associated with Meckel Syndrome Type 4 and Orofaciodigital Syndrome VI, suggesting its importance in developmental processes.
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技术参数
- 靶点基因名
- CDKL2
- 蛋白别名
- cyclin dependent kinase like 2; CDKL2
- UniProt
- Q92772
- 物种
- Human
产品详情
- 靶点名称
- CDKL2
- 蛋白名称
- cyclin dependent kinase like 2
- 蛋白别名
- Cyclin-dependent kinase-like 2; Protein kinase p56 KKIAMRE; Serine/threonine-protein kinase KKIAMRE
- 靶点基因名
- CDKL2
- UniProt
- Q92772
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cyclin dependent kinase like 2 (CDKL2) is a serine/threonine protein kinase encoded by the CDKL2 gene in humans. It is a member of the CDC2-related protein kinase family and accumulates primarily in the cytoplasm, with lower levels in the nucleus. CDKL2 exhibits ATP binding and protein serine/threonine kinase activity, playing a role in cell cycle regulation and cognitive functions. The protein is highly expressed in regions associated with cognition and emotion, such as the hippocampal formation and amygdala. CDKL2 is involved in the regulation of epithelial-mesenchymal transition (EMT) and has been implicated in tumor progression. Decreased CDKL2 expression correlates with poor prognosis in glioma. Additionally, CDKL2 has been associated with Meckel Syndrome Type 4 and Orofaciodigital Syndrome VI, suggesting its importance in developmental processes.