人 CDK16 抗体对
01AB01651
Cyclin dependent kinase 16 (CDK16) is a serine/threonine protein kinase of the cdc2/CDKx subfamily that regulates vesicle-mediated transport, exocytosis, and secretory cargo trafficking. Activated by cyclin Y family proteins, CDK16 is highly expressed in the brain and testis, where it is essential for normal spermatogenesis, neuronal differentiation, and dendrite development. It modulates physiological processes such as glucose-responsive insulin secretion and growth hormone release. Clinically, CDK16 is associated with X-linked hereditary spastic paraplegia and male infertility characterized by oligospermia. Furthermore, it is frequently overexpressed in various cancers, where it promotes cell proliferation, radioresistance, and the establishment of an immunosuppressive tumor microenvironment.
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技术参数
- 靶点基因名
- CDK16
- 基因别名
- PCTAIRE1; PCTK1
- 蛋白别名
- cyclin dependent kinase 16; CDK16
- UniProt
- Q00536
- 物种
- Human
产品详情
- 靶点名称
- CDK16
- 蛋白名称
- cyclin dependent kinase 16
- 蛋白别名
- Cyclin-dependent kinase 16; Cell division protein kinase 16; PCTAIRE-motif protein kinase 1; Serine/threonine-protein kinase PCTAIRE-1
- 靶点基因名
- CDK16
- 基因别名
- PCTAIRE1; PCTK1
- UniProt
- Q00536
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cyclin dependent kinase 16 (CDK16) is a serine/threonine protein kinase of the cdc2/CDKx subfamily that regulates vesicle-mediated transport, exocytosis, and secretory cargo trafficking. Activated by cyclin Y family proteins, CDK16 is highly expressed in the brain and testis, where it is essential for normal spermatogenesis, neuronal differentiation, and dendrite development. It modulates physiological processes such as glucose-responsive insulin secretion and growth hormone release. Clinically, CDK16 is associated with X-linked hereditary spastic paraplegia and male infertility characterized by oligospermia. Furthermore, it is frequently overexpressed in various cancers, where it promotes cell proliferation, radioresistance, and the establishment of an immunosuppressive tumor microenvironment.