人 CDHR5 抗体对
01AB03969
Cadherin-related family member 5 (CDHR5), also known as MLPCDH or MUCDHL, is a member of the cadherin superfamily and encodes a transmembrane protein with essential roles in cell adhesion and organ morphogenesis. It features four main functional domains: a cadherin domain, a mucin-like domain, a proline-rich region, and a PDZ binding motif. CDHR5 is predominantly expressed in epithelial cells of various organs, including the kidneys and lungs. Its expression has been linked to several cancers; notably, low levels of CDHR5 are associated with poor prognosis in renal cell carcinoma, colorectal cancer, and liver cancer. In pancreatic ductal adenocarcinoma (PDAC), increased CDHR5 expression correlates with tumor progression and metastasis.
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技术参数
- 靶点基因名
- CDHR5
- 基因别名
- MUCDHL; MUPCDH
- 蛋白别名
- cadherin related family member 5; CDHR5
- UniProt
- Q9HBB8
- 物种
- Human
产品详情
- 靶点名称
- CDHR5
- 蛋白名称
- cadherin related family member 5
- 蛋白别名
- Cadherin-related family member 5; Mu-protocadherin; Mucin and cadherin-like protein; Mucin-like protocadherin; MLPCDH
- 靶点基因名
- CDHR5
- 基因别名
- MUCDHL; MUPCDH
- UniProt
- Q9HBB8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cadherin-related family member 5 (CDHR5), also known as MLPCDH or MUCDHL, is a member of the cadherin superfamily and encodes a transmembrane protein with essential roles in cell adhesion and organ morphogenesis. It features four main functional domains: a cadherin domain, a mucin-like domain, a proline-rich region, and a PDZ binding motif. CDHR5 is predominantly expressed in epithelial cells of various organs, including the kidneys and lungs. Its expression has been linked to several cancers; notably, low levels of CDHR5 are associated with poor prognosis in renal cell carcinoma, colorectal cancer, and liver cancer. In pancreatic ductal adenocarcinoma (PDAC), increased CDHR5 expression correlates with tumor progression and metastasis.