人 CDH12 抗体对
01AB01451
Cadherin 12 (CDH12) is a type II classical cadherin, part of the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion, primarily through homophilic interactions where the protein binds to itself on adjacent cells. Structurally, CDH12 consists of a large N-terminal extracellular domain, a single transmembrane segment, and a small, highly conserved C-terminal cytoplasmic domain. Unlike type I cadherins, type II cadherins such as CDH12 lack the HAV cell adhesion recognition sequence. CDH12 is predominantly expressed in the brain, with its expression pattern suggesting a significant role during neuronal development, particularly in synaptogenesis. Functionally, CDH12 contributes to the maintenance of tissue architecture and cellular signaling by facilitating stable cell-cell contacts. In terms of disease association, CDH12 has been implicated in cancer biology; for example, it enhances proliferation and promotes epithelial-mesenchymal transition (EMT) in colorectal cancer cells, thereby increasing tumor progression.
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技术参数
- 靶点基因名
- CDH12
- 蛋白别名
- cadherin 12; CDH12
- UniProt
- P55289
- 物种
- Human
产品详情
- 靶点名称
- CDH12
- 蛋白名称
- cadherin 12
- 蛋白别名
- Cadherin-12; Brain cadherin; BR-cadherin; Neural type cadherin 2; N-cadherin 2
- 靶点基因名
- CDH12
- UniProt
- P55289
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cadherin 12 (CDH12) is a type II classical cadherin, part of the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion, primarily through homophilic interactions where the protein binds to itself on adjacent cells. Structurally, CDH12 consists of a large N-terminal extracellular domain, a single transmembrane segment, and a small, highly conserved C-terminal cytoplasmic domain. Unlike type I cadherins, type II cadherins such as CDH12 lack the HAV cell adhesion recognition sequence. CDH12 is predominantly expressed in the brain, with its expression pattern suggesting a significant role during neuronal development, particularly in synaptogenesis. Functionally, CDH12 contributes to the maintenance of tissue architecture and cellular signaling by facilitating stable cell-cell contacts. In terms of disease association, CDH12 has been implicated in cancer biology; for example, it enhances proliferation and promotes epithelial-mesenchymal transition (EMT) in colorectal cancer cells, thereby increasing tumor progression.