人 CDCP1 抗体对
01AB04198
CUB domain containing protein 1 (CDCP1) is a transmembrane glycoprotein with three extracellular CUB domains and an intracellular domain containing five tyrosine residues. It functions as a substrate for Src family kinases and plays a role in cell adhesion, matrix association, and signal transduction. CDCP1 undergoes proteolytic cleavage, generating amino- and carboxyl-terminal fragments. Phosphorylation of CDCP1, particularly at tyrosine 734, is crucial for its signaling functions and interaction with other proteins. CDCP1 is expressed on various cell types, including hematopoietic stem cells and cancer cells. In cancer, CDCP1 is associated with increased metastasis, tumor cell survival, and treatment resistance. Elevated CDCP1 expression has been observed in multiple cancers, including lung, colorectal.
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技术参数
- 靶点基因名
- CDCP1
- 基因别名
- TRASK
- 蛋白别名
- CUB domain containing protein 1; CDCP1
- UniProt
- Q9H5V8
- 物种
- Human
产品详情
- 靶点名称
- CDCP1
- 蛋白名称
- CUB domain containing protein 1
- 蛋白别名
- CUB domain-containing protein 1; Membrane glycoprotein gp140; Subtractive immunization M plus HEp3-associated 135 kDa protein; SIMA135; Transmembrane and associated with src kinases; CD antigen CD318
- 靶点基因名
- CDCP1
- 基因别名
- TRASK
- UniProt
- Q9H5V8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CUB domain containing protein 1 (CDCP1) is a transmembrane glycoprotein with three extracellular CUB domains and an intracellular domain containing five tyrosine residues. It functions as a substrate for Src family kinases and plays a role in cell adhesion, matrix association, and signal transduction. CDCP1 undergoes proteolytic cleavage, generating amino- and carboxyl-terminal fragments. Phosphorylation of CDCP1, particularly at tyrosine 734, is crucial for its signaling functions and interaction with other proteins. CDCP1 is expressed on various cell types, including hematopoietic stem cells and cancer cells. In cancer, CDCP1 is associated with increased metastasis, tumor cell survival, and treatment resistance. Elevated CDCP1 expression has been observed in multiple cancers, including lung, colorectal.