人 CDC42EP4 抗体对
01AB02638
CDC42 effector protein 4 (CDC42EP4), also known as BORG4, is a member of the CDC42-binding protein family that regulates actin cytoskeleton organization. It interacts with Rho family GTPases, specifically CDC42 and TC10, in a GTP-dependent manner to induce actin filament polymerization and pseudopodium assembly. In neural tissues, CDC42EP4 functions as a perisynaptic scaffold in Bergmann glia, where it complexes with septins and interacts with GLAST and myosin IIB to support glutamatergic tripartite synapses. This role is critical for maintaining synaptic integrity and function. Clinically, dysregulation of CDC42EP4 is linked to dendritic spine deficits associated with schizophrenia. Additionally, in breast tissue, its affinity for CDC42 is modulated by PKC phosphorylation, which influences Rac activation and cell motility.
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技术参数
- 靶点基因名
- CDC42EP4
- 基因别名
- BORG4; CEP4
- 蛋白别名
- CDC42 effector protein 4; CDC42EP4
- UniProt
- Q9H3Q1
- 物种
- Human
产品详情
- 靶点名称
- CDC42EP4
- 蛋白名称
- CDC42 effector protein 4
- 蛋白别名
- Cdc42 effector protein 4; Binder of Rho GTPases 4
- 靶点基因名
- CDC42EP4
- 基因别名
- BORG4; CEP4
- UniProt
- Q9H3Q1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CDC42 effector protein 4 (CDC42EP4), also known as BORG4, is a member of the CDC42-binding protein family that regulates actin cytoskeleton organization. It interacts with Rho family GTPases, specifically CDC42 and TC10, in a GTP-dependent manner to induce actin filament polymerization and pseudopodium assembly. In neural tissues, CDC42EP4 functions as a perisynaptic scaffold in Bergmann glia, where it complexes with septins and interacts with GLAST and myosin IIB to support glutamatergic tripartite synapses. This role is critical for maintaining synaptic integrity and function. Clinically, dysregulation of CDC42EP4 is linked to dendritic spine deficits associated with schizophrenia. Additionally, in breast tissue, its affinity for CDC42 is modulated by PKC phosphorylation, which influences Rac activation and cell motility.