人 CDC42BPA 抗体对
01AB02135
CDC42 binding protein kinase alpha (CDC42BPA) is a DMPK-related serine/threonine kinase that serves as a downstream effector of the Rho GTPase CDC42. It regulates actomyosin contractility, lamellipodial F-actin dynamics, and cell migration by phosphorylating key targets such as MYL9, LIMK1/2, and CFL1. The protein contains a CRIB domain for CDC42 binding and a kinase domain that mediates Rho GTPase signaling. Beyond cytoskeletal reorganization, CDC42BPA participates in TFRC-mediated iron uptake and the extrusion of apoptotic cells from epithelia. Clinically, CDC42BPA is linked to myotonic dystrophy due to its functional homology with DMPK. Additionally, altered CDC42BPA activity is implicated in the invasive and metastatic potential of various cancers, where it drives the cellular motility required for tumor progression.
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技术参数
- 靶点基因名
- CDC42BPA
- 基因别名
- KIAA0451
- 蛋白别名
- CDC42 binding protein kinase alpha; CDC42BPA
- UniProt
- Q5VT25
- 物种
- Human
产品详情
- 靶点名称
- CDC42BPA
- 蛋白名称
- CDC42 binding protein kinase alpha
- 蛋白别名
- Serine/threonine-protein kinase MRCK alpha; CDC42-binding protein kinase alpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; MRCK alpha; Myotonic dystrophy protein kinase-like alpha
- 靶点基因名
- CDC42BPA
- 基因别名
- KIAA0451
- UniProt
- Q5VT25
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CDC42 binding protein kinase alpha (CDC42BPA) is a DMPK-related serine/threonine kinase that serves as a downstream effector of the Rho GTPase CDC42. It regulates actomyosin contractility, lamellipodial F-actin dynamics, and cell migration by phosphorylating key targets such as MYL9, LIMK1/2, and CFL1. The protein contains a CRIB domain for CDC42 binding and a kinase domain that mediates Rho GTPase signaling. Beyond cytoskeletal reorganization, CDC42BPA participates in TFRC-mediated iron uptake and the extrusion of apoptotic cells from epithelia. Clinically, CDC42BPA is linked to myotonic dystrophy due to its functional homology with DMPK. Additionally, altered CDC42BPA activity is implicated in the invasive and metastatic potential of various cancers, where it drives the cellular motility required for tumor progression.