人 CDC20B 抗体对
01AB01646
Cell division cycle 20B (CDC20B) is a vertebrate-specific regulatory protein that is essential for the initiation of ciliogenesis in multiciliated cells. It localizes to the deuterosome, where it controls the disengagement of centrioles from the deuterosome structure. CDC20B is predicted to function as an activator of the anaphase-promoting complex (APC) and interacts with PLK1 and Separase to promote the release of mature centrioles, a prerequisite for basal body formation. The CDC20B gene also hosts the miR-449 cluster, which coordinates cell cycle exit with multiciliated cell differentiation. Clinically, mutations in CDC20B are associated with primary ciliary dyskinesia (PCD), a motile ciliopathy characterized by impaired mucociliary clearance and chronic respiratory disease, underscoring its fundamental role in the assembly of functional cilia.
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技术参数
- 靶点基因名
- CDC20B
- 蛋白别名
- cell division cycle 20B; CDC20B
- UniProt
- Q86Y33
- 物种
- Human
产品详情
- 靶点名称
- CDC20B
- 蛋白名称
- cell division cycle 20B
- 蛋白别名
- Cell division cycle protein 20 homolog B
- 靶点基因名
- CDC20B
- UniProt
- Q86Y33
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cell division cycle 20B (CDC20B) is a vertebrate-specific regulatory protein that is essential for the initiation of ciliogenesis in multiciliated cells. It localizes to the deuterosome, where it controls the disengagement of centrioles from the deuterosome structure. CDC20B is predicted to function as an activator of the anaphase-promoting complex (APC) and interacts with PLK1 and Separase to promote the release of mature centrioles, a prerequisite for basal body formation. The CDC20B gene also hosts the miR-449 cluster, which coordinates cell cycle exit with multiciliated cell differentiation. Clinically, mutations in CDC20B are associated with primary ciliary dyskinesia (PCD), a motile ciliopathy characterized by impaired mucociliary clearance and chronic respiratory disease, underscoring its fundamental role in the assembly of functional cilia.