抗人 CD90 抗体对
01AB00968
Thy-1 cell surface antigen (THY1), also known as CD90, is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein belonging to the immunoglobulin superfamily. It features a single V-type Ig-like domain and lacks transmembrane and cytoplasmic regions, relying on its GPI anchor for cell membrane attachment. With a molecular weight of ~18–25 kDa, THY1 is expressed in neurons, fibroblasts, and activated endothelial cells, where it regulates cell adhesion, signal transduction, apoptosis, and immune responses. THY1 is implicated in diseases such as fibrosis, cancer, and neurodegeneration. In fibrotic disorders like idiopathic pulmonary fibrosis, THY1 downregulation in fibroblasts promotes excessive extracellular matrix deposition. In cancers, including melanoma and ovarian carcinoma, THY1 acts as a tumor suppressor, with loss correlating to metastasis and poor prognosis. Additionally, THY1 modulates neuroinflammation and β-amyloid aggregation in Alzheimer’s disease, influencing disease progression.
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技术参数
- 靶点基因名
- THY1
- 蛋白别名
- Thy-1 cell surface antigen; CD90
- UniProt
- P04216
- 物种
- Human
产品详情
- 靶点名称
- CD90
- 蛋白名称
- Thy-1 cell surface antigen
- 蛋白别名
- Thy-1 membrane glycoprotein; CDw90; Thy-1 antigen; CD antigen CD90
- 靶点基因名
- THY1
- UniProt
- P04216
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Thy-1 cell surface antigen (THY1), also known as CD90, is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein belonging to the immunoglobulin superfamily. It features a single V-type Ig-like domain and lacks transmembrane and cytoplasmic regions, relying on its GPI anchor for cell membrane attachment. With a molecular weight of ~18–25 kDa, THY1 is expressed in neurons, fibroblasts, and activated endothelial cells, where it regulates cell adhesion, signal transduction, apoptosis, and immune responses. THY1 is implicated in diseases such as fibrosis, cancer, and neurodegeneration. In fibrotic disorders like idiopathic pulmonary fibrosis, THY1 downregulation in fibroblasts promotes excessive extracellular matrix deposition. In cancers, including melanoma and ovarian carcinoma, THY1 acts as a tumor suppressor, with loss correlating to metastasis and poor prognosis. Additionally, THY1 modulates neuroinflammation and β-amyloid aggregation in Alzheimer’s disease, influencing disease progression.