抗人 CD9 抗体对
01AB02952
CD9 is a tetraspanin membrane protein (also called Tspan29) with four transmembrane helices and two extracellular loops, forming part of tetraspanin-enriched microdomains that organize partner proteins such as integrins, immunoglobulin superfamily members, and metalloproteases at the plasma membrane. It regulates cell adhesion, migration, membrane curvature, and signal transduction in many cell types, including leukocytes, endothelial cells, oocytes, and cancer cells, partly by clustering adhesion receptors (for example ICAM‑1, VCAM‑1, ALCAM) and modulating ADAM17 sheddase activity. Functionally, CD9 is crucial for sperm–egg membrane fusion and female fertility, and it also influences exosome biogenesis and uptake. Clinically, altered CD9 expression is linked to cancer progression and prognosis in several tumors, where it can either promote dissemination or restrain invasion depending on context, and it serves as a diagnostic and prognostic marker in acute leukemias and a potential therapeutic target.
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技术参数
- 靶点基因名
- CD9
- 基因别名
- MIC3; TSPAN29
- 蛋白别名
- CD9 molecule; CD9
- UniProt
- P21926
- 物种
- Human
产品详情
- 靶点名称
- CD9
- 蛋白名称
- CD9 molecule
- 蛋白别名
- CD9 antigen; 5H9 antigen; Cell growth-inhibiting gene 2 protein; Leukocyte antigen MIC3; Motility-related protein; MRP-1; Tetraspanin-29; Tspan-29; p24; CD antigen CD9
- 靶点基因名
- CD9
- 基因别名
- MIC3; TSPAN29
- UniProt
- P21926
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD9 is a tetraspanin membrane protein (also called Tspan29) with four transmembrane helices and two extracellular loops, forming part of tetraspanin-enriched microdomains that organize partner proteins such as integrins, immunoglobulin superfamily members, and metalloproteases at the plasma membrane. It regulates cell adhesion, migration, membrane curvature, and signal transduction in many cell types, including leukocytes, endothelial cells, oocytes, and cancer cells, partly by clustering adhesion receptors (for example ICAM‑1, VCAM‑1, ALCAM) and modulating ADAM17 sheddase activity. Functionally, CD9 is crucial for sperm–egg membrane fusion and female fertility, and it also influences exosome biogenesis and uptake. Clinically, altered CD9 expression is linked to cancer progression and prognosis in several tumors, where it can either promote dissemination or restrain invasion depending on context, and it serves as a diagnostic and prognostic marker in acute leukemias and a potential therapeutic target.