人 CD81 抗体对
01AB00273
CD81 is a tetraspanin protein that plays important roles in various cellular processes and diseases. CD81 is expressed in many cell types and forms complexes with other tetraspanins and integrins. It has been shown to regulate cell proliferation, motility, and metastasis in several cancers, including hepatocellular carcinoma, melanoma, and osteosarcoma. High CD81 expression is associated with poorer prognosis and treatment response in acute myeloid leukemia (AML) patients. CD81 knockout promotes chemosensitivity and disrupts leukemia cell adhesion to the bone marrow microenvironment in B-cell acute lymphoblastic leukemia. In hepatocellular carcinoma, KLF4-mediated upregulation of CD9 and CD81 suppresses cell proliferation. Overall, CD81 is an important regulator of cell-cell interactions and its dysregulation contributes to cancer progression and treatment resistance.
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技术参数
- 靶点基因名
- CD81
- 基因别名
- TAPA1; TSPAN28
- 蛋白别名
- CD81 molecule; CD81
- UniProt
- P60033
- 物种
- Human
产品详情
- 靶点名称
- CD81
- 蛋白名称
- CD81 molecule
- 蛋白别名
- CD81 antigen; 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD antigen CD81
- 靶点基因名
- CD81
- 基因别名
- TAPA1; TSPAN28
- UniProt
- P60033
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD81 is a tetraspanin protein that plays important roles in various cellular processes and diseases. CD81 is expressed in many cell types and forms complexes with other tetraspanins and integrins. It has been shown to regulate cell proliferation, motility, and metastasis in several cancers, including hepatocellular carcinoma, melanoma, and osteosarcoma. High CD81 expression is associated with poorer prognosis and treatment response in acute myeloid leukemia (AML) patients. CD81 knockout promotes chemosensitivity and disrupts leukemia cell adhesion to the bone marrow microenvironment in B-cell acute lymphoblastic leukemia. In hepatocellular carcinoma, KLF4-mediated upregulation of CD9 and CD81 suppresses cell proliferation. Overall, CD81 is an important regulator of cell-cell interactions and its dysregulation contributes to cancer progression and treatment resistance.