人 CD79b 抗体对
01AB01046
CD79b molecule (CD79B) is a transmembrane glycoprotein that forms a heterodimer with CD79A to constitute the signaling component of the B-cell antigen receptor (BCR) complex, which is essential for B-cell development and activation. The CD79B protein, with a mass of approximately 25 kDa, is required for the initiation of signal transduction upon antigen binding to the BCR, leading to internalization of the complex, trafficking to late endosomes, and antigen presentation. It enhances phosphorylation of CD79A, possibly by recruiting kinases such as BLK, LYN, and SYK, and is itself phosphorylated on tyrosine residues upon B-cell activation. CD79B is encoded on chromosome 17 and exhibits protein binding, transmembrane signaling receptor activity, and homodimerization capabilities. Mutations in CD79B are associated with immunodeficiency disorders such as Agammaglobulinemia 6, Autosomal Recessive, which is characterized by a lack of mature B cells and low immunoglobulin levels, leading to increased susceptibility to infections.
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技术参数
- 靶点基因名
- CD79B
- 基因别名
- B29; IGB
- 蛋白别名
- CD79b molecule; CD79b
- UniProt
- P40259
- 物种
- Human
产品详情
- 靶点名称
- CD79b
- 蛋白名称
- CD79b molecule
- 蛋白别名
- B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD antigen CD79b
- 靶点基因名
- CD79B
- 基因别名
- B29; IGB
- UniProt
- P40259
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD79b molecule (CD79B) is a transmembrane glycoprotein that forms a heterodimer with CD79A to constitute the signaling component of the B-cell antigen receptor (BCR) complex, which is essential for B-cell development and activation. The CD79B protein, with a mass of approximately 25 kDa, is required for the initiation of signal transduction upon antigen binding to the BCR, leading to internalization of the complex, trafficking to late endosomes, and antigen presentation. It enhances phosphorylation of CD79A, possibly by recruiting kinases such as BLK, LYN, and SYK, and is itself phosphorylated on tyrosine residues upon B-cell activation. CD79B is encoded on chromosome 17 and exhibits protein binding, transmembrane signaling receptor activity, and homodimerization capabilities. Mutations in CD79B are associated with immunodeficiency disorders such as Agammaglobulinemia 6, Autosomal Recessive, which is characterized by a lack of mature B cells and low immunoglobulin levels, leading to increased susceptibility to infections.