人 CD74 抗体对
01AB01044
CD74 molecule (CD74), also known as the invariant chain, is a non-polymorphic transmembrane glycoprotein that plays a central role in the immune system by acting as a molecular chaperone for major histocompatibility complex class II (MHC II) molecules. It stabilizes peptide-free MHC II alpha/beta heterodimers after their synthesis, promotes their exit from the endoplasmic reticulum, and directs them to endocytic compartments for antigen processing and presentation. Beyond its chaperone function, CD74 serves as a high-affinity cell surface receptor for macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (D-DT/MIF2), as well as a functional receptor for tissue inhibitor of metalloproteinases-1 (TIMP-1), and regulates the transport of the angiotensin II type I receptor. Through interactions with these ligands and signaling partners such as CD44, CD74 activates multiple intracellular pathways—including PI3K/Akt, AMPK, NF-κB, and ERK—that influence B cell maturation, cell proliferation, and energy metabolism. Dysregulation of CD74 is implicated in the pathogenesis of several diseases, including ischemic heart disease, atherosclerosis, hepatic fibrosis, immunological disorders, and various cancers.
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技术参数
- 靶点基因名
- CD74
- 基因别名
- DHLAG
- 蛋白别名
- CD74 molecule; CD74
- UniProt
- P04233
- 物种
- Human
产品详情
- 靶点名称
- CD74
- 蛋白名称
- CD74 molecule
- 蛋白别名
- HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide; CLIP]
- 靶点基因名
- CD74
- 基因别名
- DHLAG
- UniProt
- P04233
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD74 molecule (CD74), also known as the invariant chain, is a non-polymorphic transmembrane glycoprotein that plays a central role in the immune system by acting as a molecular chaperone for major histocompatibility complex class II (MHC II) molecules. It stabilizes peptide-free MHC II alpha/beta heterodimers after their synthesis, promotes their exit from the endoplasmic reticulum, and directs them to endocytic compartments for antigen processing and presentation. Beyond its chaperone function, CD74 serves as a high-affinity cell surface receptor for macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (D-DT/MIF2), as well as a functional receptor for tissue inhibitor of metalloproteinases-1 (TIMP-1), and regulates the transport of the angiotensin II type I receptor. Through interactions with these ligands and signaling partners such as CD44, CD74 activates multiple intracellular pathways—including PI3K/Akt, AMPK, NF-κB, and ERK—that influence B cell maturation, cell proliferation, and energy metabolism. Dysregulation of CD74 is implicated in the pathogenesis of several diseases, including ischemic heart disease, atherosclerosis, hepatic fibrosis, immunological disorders, and various cancers.