抗人 CD73 抗体对
01AB03354
5'-nucleotidase (NT5E), also known as CD73, is an ecto-enzyme that plays a crucial role in purine metabolism by hydrolyzing extracellular adenosine monophosphate (AMP) into adenosine and inorganic phosphate. This enzymatic activity is vital for regulating adenosine levels in the extracellular space, influencing various physiological processes such as immune response, inflammation, and tissue repair. NT5E is expressed on the surface of various cell types, including lymphocytes and endothelial cells, where it also functions in cell adhesion and migration. Dysregulation of NT5E has been implicated in several diseases, particularly cancer, where it promotes tumor growth by facilitating immune evasion through the accumulation of adenosine, which inhibits T-cell activation and enhances tumor progression. Additionally, NT5E is involved in autoimmune diseases and inflammatory conditions.
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技术参数
- 靶点基因名
- NT5E
- 基因别名
- NT5; NTE
- 蛋白别名
- 5'-nucleotidase ecto; CD73
- UniProt
- P21589
- 物种
- Human
产品详情
- 靶点名称
- CD73
- 蛋白名称
- 5'-nucleotidase ecto
- 蛋白别名
- 5'-nucleotidase; 5'-NT; 5'-deoxynucleotidase; Ecto-5'-nucleotidase; IMP-specific 5'-nucleotidase; Thymidylate 5'-phosphatase; CD antigen CD73
- 靶点基因名
- NT5E
- 基因别名
- NT5; NTE
- UniProt
- P21589
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
5'-nucleotidase (NT5E), also known as CD73, is an ecto-enzyme that plays a crucial role in purine metabolism by hydrolyzing extracellular adenosine monophosphate (AMP) into adenosine and inorganic phosphate. This enzymatic activity is vital for regulating adenosine levels in the extracellular space, influencing various physiological processes such as immune response, inflammation, and tissue repair. NT5E is expressed on the surface of various cell types, including lymphocytes and endothelial cells, where it also functions in cell adhesion and migration. Dysregulation of NT5E has been implicated in several diseases, particularly cancer, where it promotes tumor growth by facilitating immune evasion through the accumulation of adenosine, which inhibits T-cell activation and enhances tumor progression. Additionally, NT5E is involved in autoimmune diseases and inflammatory conditions.