人 CD70 抗体对
01AB03965
CD70 antigen (CD70) is a type II transmembrane protein that serves as a ligand for the CD27 receptor, playing a vital role in the immune response by promoting T and B cell activation. It is primarily expressed on activated T and B lymphocytes, as well as on dendritic cells, where its expression is transient and regulated by various cytokines such as IL-1α, IL-2, and TNF-α. The interaction between CD70 and CD27 enhances immune responses by activating signaling pathways that lead to T cell proliferation and differentiation. Dysregulation of CD70 expression has been associated with several diseases, particularly cancers like Hodgkin's lymphoma and non-Hodgkin's lymphoma, where its overexpression contributes to tumor growth and survival. Additionally, high levels of CD70 have been implicated in autoimmune diseases due to their role in excessive immune activation.
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技术参数
- 靶点基因名
- CD70
- 基因别名
- CD27L; CD27LG; TNFSF7
- 蛋白别名
- CD70 molecule; CD70
- UniProt
- P32970
- 物种
- Human
产品详情
- 靶点名称
- CD70
- 蛋白名称
- CD70 molecule
- 蛋白别名
- CD70 antigen; CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD antigen CD70
- 靶点基因名
- CD70
- 基因别名
- CD27L; CD27LG; TNFSF7
- UniProt
- P32970
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD70 antigen (CD70) is a type II transmembrane protein that serves as a ligand for the CD27 receptor, playing a vital role in the immune response by promoting T and B cell activation. It is primarily expressed on activated T and B lymphocytes, as well as on dendritic cells, where its expression is transient and regulated by various cytokines such as IL-1α, IL-2, and TNF-α. The interaction between CD70 and CD27 enhances immune responses by activating signaling pathways that lead to T cell proliferation and differentiation. Dysregulation of CD70 expression has been associated with several diseases, particularly cancers like Hodgkin's lymphoma and non-Hodgkin's lymphoma, where its overexpression contributes to tumor growth and survival. Additionally, high levels of CD70 have been implicated in autoimmune diseases due to their role in excessive immune activation.