人 CD69 抗体对
01AB01930
CD69 molecule (CD69) is a type II transmembrane C-type lectin that forms a disulfide-linked homodimer and serves as one of the earliest inducible activation markers on leukocytes, including T cells and NK cells. It is highly expressed on tissue-resident T cells, where it regulates lymphocyte retention by acting as a cis-acting agonist of sphingosine-1-phosphate receptor 1, promoting its internalization and thereby inhibiting tissue egress. Additionally, CD69 associates with the amino acid transporter LAT1 to modulate mTOR-dependent metabolism, which shapes cytokine production and T helper cell differentiation. Through these mechanisms, CD69 plays a pivotal role in controlling the duration and nature of local immune responses and regulatory T-cell function.
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技术参数
- 靶点基因名
- CD69
- 基因别名
- CLEC2C
- 蛋白别名
- CD69 molecule; CD69
- UniProt
- Q07108
- 物种
- Human
产品详情
- 靶点名称
- CD69
- 蛋白名称
- CD69 molecule
- 蛋白别名
- Early activation antigen CD69; Activation inducer molecule; AIM; BL-AC/P26; C-type lectin domain family 2 member C; EA1; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3; CD antigen CD69
- 靶点基因名
- CD69
- 基因别名
- CLEC2C
- UniProt
- Q07108
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD69 molecule (CD69) is a type II transmembrane C-type lectin that forms a disulfide-linked homodimer and serves as one of the earliest inducible activation markers on leukocytes, including T cells and NK cells. It is highly expressed on tissue-resident T cells, where it regulates lymphocyte retention by acting as a cis-acting agonist of sphingosine-1-phosphate receptor 1, promoting its internalization and thereby inhibiting tissue egress. Additionally, CD69 associates with the amino acid transporter LAT1 to modulate mTOR-dependent metabolism, which shapes cytokine production and T helper cell differentiation. Through these mechanisms, CD69 plays a pivotal role in controlling the duration and nature of local immune responses and regulatory T-cell function.