抗人 CD6 抗体对
01AB02792
T-cell differentiation antigen CD6 (CD6) is a type I transmembrane glycoprotein primarily expressed on T lymphocytes, playing a crucial role in immune responses. CD6 interacts with its ligand, CD166, enhancing T-cell activation and promoting cell survival. This interaction is essential for the formation of a signaling complex that modulates T-cell responses, making CD6 a potential co-stimulatory receptor. However, its role can be context-dependent, exhibiting both co-stimulatory and inhibitory functions based on the cellular environment and the specific immune context. Dysregulation of CD6 has been implicated in various autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it may contribute to the pathogenesis by affecting T-cell activation and differentiation. In these conditions, altered CD6 expression can lead to excessive T-cell activation, promoting inflammation and tissue damage.
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技术参数
- 靶点基因名
- CD6
- 蛋白别名
- CD6 molecule; CD6
- UniProt
- P30203
- 物种
- Human
产品详情
- 靶点名称
- CD6
- 蛋白名称
- CD6 molecule
- 蛋白别名
- T-cell differentiation antigen CD6; T12; TP120; CD antigen CD6) [Cleaved into: Soluble CD6]
- 靶点基因名
- CD6
- UniProt
- P30203
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
T-cell differentiation antigen CD6 (CD6) is a type I transmembrane glycoprotein primarily expressed on T lymphocytes, playing a crucial role in immune responses. CD6 interacts with its ligand, CD166, enhancing T-cell activation and promoting cell survival. This interaction is essential for the formation of a signaling complex that modulates T-cell responses, making CD6 a potential co-stimulatory receptor. However, its role can be context-dependent, exhibiting both co-stimulatory and inhibitory functions based on the cellular environment and the specific immune context. Dysregulation of CD6 has been implicated in various autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it may contribute to the pathogenesis by affecting T-cell activation and differentiation. In these conditions, altered CD6 expression can lead to excessive T-cell activation, promoting inflammation and tissue damage.