抗人 CD59 抗体对
01AB03719
CD59 molecule (CD59 blood group) (CD59), also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a glycoprotein that plays a crucial role in protecting human cells from complement-mediated lysis. It is encoded by the CD59 gene and is expressed in all organs and almost all cell types. CD59 functions by inhibiting the formation of the membrane attack complex (MAC) by binding to complement proteins C8 and C9, preventing pore formation and cell lysis. Mutations affecting the glycophosphatidylinositol (GPI) anchor that attaches CD59 to host cells can lead to diseases such as paroxysmal nocturnal hemoglobinuria. Additionally, viruses like HIV and human cytomegalovirus incorporate host cell CD59 into their viral envelopes to evade complement-mediated lysis.
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技术参数
- 靶点基因名
- CD59
- 基因别名
- MIC11; MIN1; MIN2; MIN3; MSK21
- 蛋白别名
- CD59 molecule (CD59 blood group); CD59
- UniProt
- P13987
- 物种
- Human
产品详情
- 靶点名称
- CD59
- 蛋白名称
- CD59 molecule (CD59 blood group)
- 蛋白别名
- CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD antigen CD59
- 靶点基因名
- CD59
- 基因别名
- MIC11; MIN1; MIN2; MIN3; MSK21
- UniProt
- P13987
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD59 molecule (CD59 blood group) (CD59), also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a glycoprotein that plays a crucial role in protecting human cells from complement-mediated lysis. It is encoded by the CD59 gene and is expressed in all organs and almost all cell types. CD59 functions by inhibiting the formation of the membrane attack complex (MAC) by binding to complement proteins C8 and C9, preventing pore formation and cell lysis. Mutations affecting the glycophosphatidylinositol (GPI) anchor that attaches CD59 to host cells can lead to diseases such as paroxysmal nocturnal hemoglobinuria. Additionally, viruses like HIV and human cytomegalovirus incorporate host cell CD59 into their viral envelopes to evade complement-mediated lysis.