抗人 CD40L 抗体对
01AB01042
CD40 ligand (CD40LG), also known as CD154, is a type II transmembrane glycoprotein expressed primarily on activated T cells. It belongs to the tumor necrosis factor (TNF) superfamily and plays a critical role in immune regulation by binding to its receptor, CD40, on antigen-presenting cells such as B cells, dendritic cells, and macrophages. This interaction triggers signaling pathways that regulate immunoglobulin class switching, antibody production, and the activation of NF-κB and MAPK pathways. CD40LG is essential for T-cell-mediated "help" in B-cell activation and differentiation, enabling the production of IgG, IgA, and IgE antibodies. It also contributes to cytokine production and enhances immune responses through integrin-mediated signaling. Mutations in the CD40LG gene are associated with X-linked hyper-IgM syndrome, a rare immunodeficiency disorder characterized by impaired antibody class switching and increased susceptibility to infections. Abnormal CD40LG expression has also been linked to autoimmune diseases and certain cancers.
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技术参数
- 靶点基因名
- CD40LG
- 基因别名
- CD40L; TNFSF5; TRAP
- 蛋白别名
- CD40 ligand; CD40L
- UniProt
- P29965
- 物种
- Human
产品详情
- 靶点名称
- CD40L
- 蛋白名称
- CD40 ligand
- 蛋白别名
- CD40 ligand; CD40-L; T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5; CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form; sCD40L]
- 靶点基因名
- CD40LG
- 基因别名
- CD40L; TNFSF5; TRAP
- UniProt
- P29965
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD40 ligand (CD40LG), also known as CD154, is a type II transmembrane glycoprotein expressed primarily on activated T cells. It belongs to the tumor necrosis factor (TNF) superfamily and plays a critical role in immune regulation by binding to its receptor, CD40, on antigen-presenting cells such as B cells, dendritic cells, and macrophages. This interaction triggers signaling pathways that regulate immunoglobulin class switching, antibody production, and the activation of NF-κB and MAPK pathways. CD40LG is essential for T-cell-mediated "help" in B-cell activation and differentiation, enabling the production of IgG, IgA, and IgE antibodies. It also contributes to cytokine production and enhances immune responses through integrin-mediated signaling. Mutations in the CD40LG gene are associated with X-linked hyper-IgM syndrome, a rare immunodeficiency disorder characterized by impaired antibody class switching and increased susceptibility to infections. Abnormal CD40LG expression has also been linked to autoimmune diseases and certain cancers.