抗人 CD38 抗体对
01AB02990
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) is a multifunctional enzyme that plays a pivotal role in calcium signaling and immune response regulation. It catalyzes the synthesis of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) from NAD+, which are crucial second messengers for calcium mobilization in cells. CD38 is expressed on various immune cells, including T and B lymphocytes, where it acts as both an enzyme and a receptor, influencing cell activation and proliferation. Dysregulation of CD38 has been implicated in several diseases, such as leukemias and myelomas, where its expression is often elevated and associated with tumor progression. Additionally, CD38 is linked to autoimmune diseases and metabolic disorders, including type 2 diabetes, where it may affect insulin secretion and sensitivity.
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技术参数
- 靶点基因名
- CD38
- 蛋白别名
- CD38 molecule; CD38
- UniProt
- P28907
- 物种
- Human
产品详情
- 靶点名称
- CD38
- 蛋白名称
- CD38 molecule
- 蛋白别名
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPR hydrolase 1; T10; CD antigen CD38
- 靶点基因名
- CD38
- UniProt
- P28907
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) is a multifunctional enzyme that plays a pivotal role in calcium signaling and immune response regulation. It catalyzes the synthesis of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) from NAD+, which are crucial second messengers for calcium mobilization in cells. CD38 is expressed on various immune cells, including T and B lymphocytes, where it acts as both an enzyme and a receptor, influencing cell activation and proliferation. Dysregulation of CD38 has been implicated in several diseases, such as leukemias and myelomas, where its expression is often elevated and associated with tumor progression. Additionally, CD38 is linked to autoimmune diseases and metabolic disorders, including type 2 diabetes, where it may affect insulin secretion and sensitivity.