人 CD36 抗体对
01AB03242
CD36 molecule (CD36 blood group) (CD36) is a multifunctional class B scavenger receptor and heavily glycosylated membrane glycoprotein that facilitates the uptake of long-chain fatty acids and other diverse ligands. It binds to thrombospondin, collagen, oxidized LDL, and anionic phospholipids, playing a central role in cell adhesion, lipid metabolism, and innate immune signaling. CD36 is highly expressed in platelets, macrophages, and adipocytes, where it contributes to foam cell formation and metabolic homeostasis. Clinically, pathogenic variants or deficiency of CD36 lead to platelet glycoprotein IV deficiency, an inherited condition associated with altered platelet reactivity and increased risk of cardiometabolic diseases and atherosclerosis.
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技术参数
- 靶点基因名
- CD36
- 基因别名
- GP3B; GP4
- 蛋白别名
- CD36 molecule (CD36 blood group); CD36
- UniProt
- P16671
- 物种
- Human
产品详情
- 靶点名称
- CD36
- 蛋白名称
- CD36 molecule (CD36 blood group)
- 蛋白别名
- Platelet glycoprotein 4; Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor; CD antigen CD36
- 靶点基因名
- CD36
- 基因别名
- GP3B; GP4
- UniProt
- P16671
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD36 molecule (CD36 blood group) (CD36) is a multifunctional class B scavenger receptor and heavily glycosylated membrane glycoprotein that facilitates the uptake of long-chain fatty acids and other diverse ligands. It binds to thrombospondin, collagen, oxidized LDL, and anionic phospholipids, playing a central role in cell adhesion, lipid metabolism, and innate immune signaling. CD36 is highly expressed in platelets, macrophages, and adipocytes, where it contributes to foam cell formation and metabolic homeostasis. Clinically, pathogenic variants or deficiency of CD36 lead to platelet glycoprotein IV deficiency, an inherited condition associated with altered platelet reactivity and increased risk of cardiometabolic diseases and atherosclerosis.