人 CD32 抗体对
01AB01481
Fc gamma receptor IIa (FCGR2A) is a low-affinity receptor protein found on the surface of many immune response cells, including macrophages and neutrophils. It binds to the Fc region of immunoglobulin G (IgG) and initiates cellular responses against pathogens and soluble antigens, promoting phagocytosis of opsonized antigens. FCGR2A is involved in various immune processes, including neutrophil degranulation and cell adhesion. The protein is encoded by the FCGR2A gene located on chromosome 1. FCGR2A plays a crucial role in the innate immune system and has been associated with several diseases, including autoimmune disorders such as systemic lupus erythematosus and cystic fibrosis. Additionally, it has been implicated in susceptibility to infectious diseases like malaria and in the pathogenesis of certain cancers, such as gastrointestinal stromal tumors.
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技术参数
- 靶点基因名
- FCGR2A
- 基因别名
- CD32; FCG2; FCGR2A1; IGFR2
- 蛋白别名
- Fc gamma receptor IIa; CD32
- UniProt
- P12318
- 物种
- Human
产品详情
- 靶点名称
- CD32
- 蛋白名称
- Fc gamma receptor IIa
- 蛋白别名
- Low affinity immunoglobulin gamma Fc region receptor II-a; IgG Fc receptor II-a; CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD antigen CD32
- 靶点基因名
- FCGR2A
- 基因别名
- CD32; FCG2; FCGR2A1; IGFR2
- UniProt
- P12318
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Fc gamma receptor IIa (FCGR2A) is a low-affinity receptor protein found on the surface of many immune response cells, including macrophages and neutrophils. It binds to the Fc region of immunoglobulin G (IgG) and initiates cellular responses against pathogens and soluble antigens, promoting phagocytosis of opsonized antigens. FCGR2A is involved in various immune processes, including neutrophil degranulation and cell adhesion. The protein is encoded by the FCGR2A gene located on chromosome 1. FCGR2A plays a crucial role in the innate immune system and has been associated with several diseases, including autoimmune disorders such as systemic lupus erythematosus and cystic fibrosis. Additionally, it has been implicated in susceptibility to infectious diseases like malaria and in the pathogenesis of certain cancers, such as gastrointestinal stromal tumors.